74786-16-6

Basic information

• Product Name: Benzene, [1-(difluoromethylene)-2,3,3-trifluoro-2-propenyl]-
• CAS NO: 74786-16-6
• Molecular Formula: C10H5F5
• Molecular Weight: 220.142
• Mol File: 74786-16-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzene, [1-(difluoromethylene)-2,3,3-trifluoro-2-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, [1-(difluoromethylene)-2,3,3-trifluoro-2-propenyl]-(74786-16-6)
• EPA Substance Registry System: Benzene, [1-(difluoromethylene)-2,3,3-trifluoro-2-propenyl]-(74786-16-6)

Safety Data

• Hazardous Substances Data: 74786-16-6(Hazardous Substances Data)

Upstream product

• 1979-51-7 1,1,3,3,3-pentafluoro-2-phenylpropene 
• 359-37-5 Iodotrifluoroethylene 
• 74492-30-1 α-bromo-β,β-difluorostyrene 
• 74786-21-3 ((Z)-1,1,2,4,4,4-Hexafluoro-3-phenyl-but-2-enyl)-triphenyl-phosphonium; bromide 

Relevant articles and documents

New efficient approach to 2,2-diaryl-1,1-difluoro-1-alkenes and 1,1-difluoro-2-aryl-1,3-dienes via Suzuki coupling of α-halo-β, β-difluorostyrenes

α-Halo-β,β-difluorostyrenes [ArCX = CF2; X = Br, I; Ar = aryl, heteroaryl; synthesized by the Pd(0)-catalyzed coupling reaction of the corresponding α-halo-β,β-difluoroethenylzinc reagents (CF2=CXZnCl, X = Br, I) with aryl iodides] were functionalized at the halogen site with arylboronic acids under Pd(0)-catalyzed Suzuki-Miyaura coupling reaction conditions to obtain 2,2-diaryl-1,1-difluoro-1-alkenes (ArAr'C=CF2, Ar' = aryl, heteroaryl) in 51-91% isolated yield. The corresponding reaction with alkenylboronic acids produced 1,1-difluoro-2-aryl-1, 3-dienes in 53-80% isolated yield. Alternatively, 2,2-disubstituted-1,1- difluoro-1-alkenes were synthesized in moderate yield by a zinc-insertion reaction at the halogen site of the α-halo-β,β-difluorostyrenes, followed by Pd(0)-catalyzed cross-coupling of the zinc reagent with aryl or alkenyl iodides.