7479-20-1

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with diverse therapeutic applications.
Used in Anti-Inflammatory and Immunosuppressive Applications:
In the medical field, 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID is used as an anti-inflammatory and immunosuppressive agent, leveraging its potential to modulate immune responses and reduce inflammation, which is crucial for treating conditions characterized by excessive immune activity or chronic inflammation.
Used in Research and Development of Neurodegenerative Disorders:
3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID is utilized as a research compound in the study of neurodegenerative disorders, given its potential therapeutic effects and the need to understand its impact on neurological conditions.
Used in Cancer Research:
In oncology, 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID is used as a research tool to explore its role in cancer treatment, with the aim of identifying its potential as a therapeutic agent against various types of cancer.
Used in Autoimmune Disease Research:
3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID is employed in the investigation of autoimmune diseases, focusing on its capacity to regulate immune responses and potentially mitigate the effects of these conditions.
Each application underscores the versatility and significance of 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID in advancing medical science and pharmaceutical development.

InChI:InChI=1/C12H13NO2/c1-13-8-9(6-7-12(14)15)10-4-2-3-5-11(10)13/h2-5,8H,6-7H2,1H3,(H,14,15)

Upstream product

• 855658-22-9 (1-methyl-indol-3-ylmethyl)-malonic acid 
• 57901-08-3 1-methylindole-3-propionic acid methyl ester 
• 19260-05-0 1-methylgramine methiodide 
• 830-96-6 Indole-3-propionic acid 
• 603-76-9 1-methylindole 
• 79-10-7 acrylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 909568-50-9 N-(2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-51-0 N-(4-chloro-2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 1323359-82-5 7-[4-(dimethylamino)phenyl]-4-methyl-1,4-dihydro-2H-cyclopenta[b]indol-3-one 
• 205884-12-4 (2E)-3-(1-methyl-1H-indol-3-yl)prop-2-enoic acid 
• 839685-22-2 4-methyl-3-phenyl-1,2,3,4-tetrahydrocyclopenta[b]indol-3-ol 
• 909568-62-3 N-(2-bromobenzyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-60-1 N-(4-chloro-2-iodophenyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 909568-59-8 N-(2-iodophenyl)-N-methyl-3-(1-methyl-1H-indol-3-yl)propionamide 
• 892386-15-1 N-(2-bromobenzyl)-3-(1-methyl-1H-indol-3-yl)propionamide 
• 1616472-11-7 4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate 

Relevant academic research and scientific papers

3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF

The present disclosure describes novel compounds that are somatostatin receptor type 4 agonists.

Sodium Iodide/Hydrogen Peroxide-Mediated Oxidation/Lactonization for the Construction of Spirocyclic Oxindole-Lactones

The sodium iodide/hydrogen peroxide-mediated oxidation/lactonization of indolepropionic acids was achieved, affording the corresponding spirocyclic oxindole-lactones in moderate to high yields. This metal-free procedure features mild reaction conditions, non-toxicity and easy handling, with hydrogen peroxide (H2O2) as a clean oxidant. (Figure presented.).

CuCl2/TBHP-mediated direct chlorooxidation of indoles

CuCl2/TBHP-mediated direct chlorooxidation of indole derivatives under simple aerobic conditions was reported, leading to facile preparations of a range of 3,3-disubstituted 3-chlorooxindoles in good yields and selectivities.

Thee-component, one-pot synthesis of hexahydroazepino[3,4-b]indole and tetrahydro-1H-pyrido[3,4-b]indole derivatives and evaluation of their cytotoxicity

A three-component, four-center Ugi reaction has been developed to produce a novel class of 2-aryl-3-oxo-hexahydroazepino[3,4-b]indole and 2-aryl-3-oxo-tetrahydro-1H-pyrido[3,4-b]indole derivatives in good to high yields. A few of them exhibit moderate cyt

New potent fluorescent analogues of strigolactones: Synthesis and biological activity in parasitic weed germination and fungal branching

In this work we report the synthesis of new fluorescent analogues of strigolactones, their spectroscopic properties and the evaluation of their biological activity both on seeds of Orobanche aegyptiaca and on the AM fungus Gigaspora margarita. The synthes

SMALL MOLECULE INHIBITORS OF HEPATITIS C VIRUS

The invention provides derivatives and analogues of triazatetracyclo[7.7.0.01,13,.02,7]-hexadeca-2,4,6,10,12-pentaenes, 5,7,11-triazatetracyclo[8.7.0.01,6.012,17] -heptadeca- 6,8,12,14,16-pentaenes, pharmaceutical compositions comprising these compounds and methods for treatment of hepatitis C viral infections using these compounds.

Efficient synthesis of tetrahydro-b-carbolin-1-one and dihydroisoquinolin- 1-one derivatives as versatile Intermediates

An efficient one-pot procedure is described in which an isocyanate intermediate, generated from the corresponding carboxylic acid by a modified Curtius rearrangement, is captured by a tethered aromatic ring in the presence of BF3?OEt2 to generate various

New small molecule inhibitors of hepatitis C virus

New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.

Addition of heterocycles to electron deficient olefins and alkynes catalyzed by gold(III)

A gold(III)-catalyzed hydroarylation of different olefins is reported here. AuCl3 works as an excellent catalyst to mediate reactions between various heterocycles and electron deficient olefins and alkynes under mild conditions. This gold(III)-based method tolerates different functional groups such as aldehyde, carboxylic acid, nitrile, and is highly efficient. We have shown that some of these reactions complete in minutes at room temperature.

Intramolecular Ritter reactions of 2-(2-cyanoethyl)tetrahydrocyclopenta-[b] indole and -carbazole derivatives

Intramolecular Ritter reactions of 2-(2-cyanoethyl)tetrahydrocyclopenta[b] indole and -carbazole derivatives, prepared by a sequence of two different α-substitutions and Grignard reactions of the indole-based ketones 4-methyl-1,4-dihydrocyclopenta[b]indol-3(2H)-one and 9-methyl-2,3,4,9- tetrahydro-1H-carbazol-1-one, were used as key steps in the construction of various tetracyclic lactam compounds. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.