3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

Base Information

• Chemical Name: 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID
• CAS No.: 7479-20-1
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Hs Code.: 2933990090
• Mol file: 7479-20-1.mol

Synonyms:3-(1-Methyl-1H-indol-3-yl)-propionic acid;(1-methyl-1H-indol-3-yl)propionic acid;3-(3-n-methylindolyl)propionic acid;3-(1-methyl-indol-3-yl)-propionic acid;N-methyl-indol-3-ylpropanoic acid;3-(1-methyl-1H-indol-3-yl)propanoic acid;

Chemical Property of 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

Chemical Property:

• Vapor Pressure: 4.21E-07mmHg at 25°C
• Boiling Point: 399.6°Cat760mmHg
• Flash Point: 195.4°C
• PSA: 42.23000
• Density: 1.17g/cm³
• LogP: 2.19550

Purity/Quality:

99% ^*data from raw suppliers

3-(1-methyl-1H-indol-3-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID

There total 7 articles about 3-(1-METHYL-1H-INDOL-3-YL)-PROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Indole-3-propionic acid (830-96-6) + methyl iodide (74-88-4) → N-methyl-3-(indol-3-yl)propionic acid (7479-20-1)

Guidance literature:

Indole-3-propionic acid; methyl iodide; With potassium hydroxide; In acetone; at 20 ℃; for 4h;

With potassium hydroxide; In water; for 2h; Further stages.; Heating;

DOI:10.1002/ejoc.200400409

Reference yield: 86.0%

1-methylindole (603-76-9) + acrylic acid (79-10-7) → N-methyl-3-(indol-3-yl)propionic acid (7479-20-1)

Guidance literature:

In acetic anhydride; acetic acid; for 3h; Heating;

DOI:10.1023/B:RUCB.0000037860.62546.33

Reference yield: 78.0%

1-methylindole-3-propionic acid methyl ester (57901-08-3) → N-methyl-3-(indol-3-yl)propionic acid (7479-20-1)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

upstream raw materials:

(1-methyl-indol-3-ylmethyl)-malonic acid

1-methylindole-3-propionic acid methyl ester

Indole-3-propionic acid

methyl iodide

Downstream raw materials:

N-(2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide

N-(4-chloro-2-iodophenyl)-3-(1-methyl-1H-indol-3-yl)propionamide

3-(4-methyl-3-phenyl-1,4-dihydrocyclopenta[b]indol-2-yl)propanenitrile

N-Methyl-1,2-Phthaloylcarbazol

Refernces

• 1、 -. "3,4,5-TRISUBSTITUTED-1,2,4-TRIAZOLES AND 3,4,5-TRISUBSTITUTED-3-THIO-1,2,4-TRIAZOLES AND USES THEREOF". Paragraph 0158; 0168. . Retrieved 2018/12/02.
• 2、 Wang, Huifei,Liu, Dong,Chen, Huiyu,Li, Jing,Wang, David Zhigang. "CuCl2/TBHP-mediated direct chlorooxidation of indoles". supporting information. p. 7073 - 7076. Retrieved 2015/08/19.