74805-89-3 Usage
Uses
Used in Pharmaceutical Industry:
Methylophiopogonone B is used as a therapeutic agent for conditions such as asthma and atopic dermatitis due to its anti-inflammatory and anti-allergic properties. It helps in managing symptoms and reducing inflammation associated with these conditions.
Used in Antioxidant Applications:
Methylophiopogonone B is used as an antioxidant to combat oxidative stress, which is implicated in various diseases such as cardiovascular disorders and aging-related disorders. Its antioxidant activity helps in preventing and treating conditions associated with oxidative stress.
Used in Research and Development:
Methylophiopogonone B is used in ongoing research to explore its pharmacological effects and potential medical applications further. This includes studying its mechanisms of action, safety, and efficacy in treating various inflammatory and oxidative stress-related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 74805-89-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,4,8,0 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 74805-89:
(7*7)+(6*4)+(5*8)+(4*0)+(3*5)+(2*8)+(1*9)=153
153 % 10 = 3
So 74805-89-3 is a valid CAS Registry Number.
74805-89-3Relevant academic research and scientific papers
An Efficient Regioselective Synthesis of 8-Formylhomoisoflavonoids with Neuroprotective Activity by Enhancing Autophagy
Li, Jie,Yang, Fan,Zeng, Lin-Wei,Zhang, Fang-Min,Zhou, Chang-Xin,Gan, Li-She
, p. 1385 - 1391 (2021/04/12)
6-Formylisoophiopogonone B (7a) and 8-formylophiopogonone B (7b), two natural products isolated fromOphiopogonjaponicus, represent a subgroup of rare 6/8-formyl/methyl-homoisoflavonoid skeletons. Herein we report an efficient method for the synthesis of these formyl/methyl-homoisoflavonoids. The synthesized compounds were evaluated for their neuroprotective effects on the MPP+-induced SH-SY5Y cell injury model and showed marked activity. Exploration of the neuroprotective mechanisms of compound7bled to an increased expression of autophagy marker LC3-II and down-regulation of autophagy substrate p62/SQSTM1. Molecular docking studies showed that7bmay prevent the inhibition of the classic PI3K-AKT-mTOR signaling pathway by interfering with the human HSP90AA1.
