74809-00-0

Usage

Uses

Used in Pharmaceutical Applications:
2,4-dimethyl-6-phenyl-1,2,4,5-tetrazinan-3-one is used as a precursor in the synthesis of bioactive compounds for pharmaceutical purposes. Its unique structure allows for the creation of new molecules with potential therapeutic properties.
Used in Drug Delivery Systems:
In the field of drug delivery, 2,4-dimethyl-6-phenyl-1,2,4,5-tetrazinan-3-one is utilized as a component in the design of novel systems aimed at improving the efficacy and targeted delivery of therapeutic agents. Its chemical properties facilitate its integration into various drug carrier platforms.
Used in Organic Synthesis:
2,4-dimethyl-6-phenyl-1,2,4,5-tetrazinan-3-one is used as a key building block in the synthesis of heterocyclic compounds. Its presence in the molecular structure can influence the reactivity and final properties of the synthesized compounds, making it an essential component in organic chemistry research and development.

Upstream product

• 13782-38-2 2,4-dimethylcarbonohydrazide 
• 100-52-7 benzaldehyde 
• 13915-68-9 benzaldehyde 2-chloroformyl-2-methylhydrazone 
• 60-34-4 methylhydrazine 
• 4114-25-4 1,5-dibenzylidenecarbonohydrazide 
• 13782-37-1 1,5-Dibenzyliden-2,4-dimethylcarbonohydrazid 

Downstream Products

• 74809-03-3 1,4-Dihydro-2,4-dimethyl-6-phenyl-1,2,4,5-tetrazin-3(2H)-on 
• 74809-04-4 1,4-Dihydro-1,2,4-trimethyl-6-phenyl-1,2,4,5-tetrazin-3(2H)-on 
• 112113-52-7 2-Methyl-6-phenyl-1,2,4,5-tetrazin-3(2H)-on 
• 112113-48-1 1-(1-cyan-1-methylethyl)-1,4-dihydro-2,4-dimethyl-6-phenyl-1,2,4,5-tetrazin-3(2H)-on 
• 112113-46-9 1-Benzyl-1,4-dihydro-2,4-dimethyl-6-phenyl-1,2,4,5-tetrazin-3(2H)-on 
• 112113-51-6 2,9-Dimethyl-4,11-diphenyl-6H,13H-di<1,2,4,5>tetrazino<1,2-a:1',2'-d><1,2,4,5>tetrazin-1,8(2H,9H)-dion 

Relevant academic research and scientific papers

A hydrazine- and phosgene-free synthesis of tetrazinanones, precursors to 1,5-dialkyl-6-oxoverdazyl radicals

A complementary approach to published synthetic methods for tetrazinanones, precursors to verdazyl radicals, is described herein. This approach uses carbohydrazide, a commercially available reagent, as a common starting material. Unlike previous methods d

1,3-Dipolar cycloaddition reactions initiated with the 1,5-dimethyl-3- phenyl-6-oxoverdazyl radical

The 1,5-dimethyl-3-phenyl-6-oxoverdazyl radical reacts at room temperature in the presence of styrene to give a dihydrotetrazinone heterocyclic structure. We surmise that the reaction occurs by a 1,3-dipolar cycloaddition via the intermediacy of an azomet

New General Synthesis of Tetrahydro-1,2,4,5-tetrazin-3(2H)-one Derivatives and Stable 3,4-Dihydro-3-oxo-1,2,4,5-tetrazin-1(2H)-yl Radical Derivatives

Reactions of 2-chloroformylhydrazones of aromatic aldehydes or ketones 2 with various hydrazines were converted to monocarbonohydrazone derivatives 3 or 5 and/or tetrahydro-1,2,4,5-tetrazin-3(2H)-one derivatives 6,7.By oxidation with lead dioxide, compounds 6 were transformed into stable 3,4-dihydro-3-oxo-1,2,4,5-tetrazin-1(2H)-yl radical derivatives 8.

2,4-Dialkyl Substituted Carbono- and Thiocarbonohydrazides, Reactions with Carbonyl Compounds

2,4-Dialkyl substituted carbono- and thiocarbonohydrazides (4) were prepared from alkylhydrazines and phosgene or thiophosgene.Mono carbonyl compounds reacted with 4 (molar ratio 1:1) to yield hexahydro-1,2,4,5-tetrazines (9, 14; exception 13).Aldehydes in excess generally afforded dihydrazones (3); formaldehyde, however, yielded 1,1'-methylenebis(hexahydro-1,2,4,5-tetrazines) (10) as well as the bicyclic compounds 11 and 12.The constitution of 11 was confirmed by X-ray analysis of 11b.Dialdehydes and aliphatic or alicyclic α-diketones reacted with 4 to give double hexahydro-1,2,4,5-tetrazine derivatives (19), aryl substituted α-diketones on the other hand yielded cyclic dihydrazones (15) and/or mono-hexahydro-1,2,4,5-tetrazines (16).