7483-59-2

Usage

Uses

Used in Pharmaceutical Industry:
3-(1-Piperazinyl)-1,2-propanediol is used as a pharmaceutical intermediate for the synthesis of various drugs, particularly antipsychotic and antidepressant medications. Its presence in these formulations aids in enhancing the solubility and absorption of the drugs, which is essential for improving their therapeutic effects.
Used in Drug Formulation:
3-(1-Piperazinyl)-1,2-propanediol is utilized in drug formulations to improve the solubility and absorption of certain medications. This enhancement is critical for the drugs' effectiveness, as it allows for better bioavailability and therapeutic action within the body.
Used in Medical Research:
3-(1-Piperazinyl)-1,2-propanediol is used in medical research for exploring its potential applications in treating various conditions, including anxiety disorders and irritable bowel syndrome. Its unique structure and properties make it a promising candidate for the development of new therapeutic agents.

InChI:InChI=1/C7H16N2O2/c10-6-7(11)5-9-3-1-8-2-4-9/h7-8,10-11H,1-6H2

Upstream product

• 110-85-0 piperazine 
• 556-52-5 oxiranyl-methanol 
• 96-24-2 3-monochloro-1,2-propanediol 
• 56-81-5 glycerol 

Downstream Products

• 80273-37-6 3-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-propane-1,2-diol 
• 280-57-9 1,4-diaza-bicyclo[2.2.2]octane 
• 76950-43-1 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane 
• 110-85-0 piperazine 

Relevant academic research and scientific papers

METHOD FOR PRODUCING BICYCLIC AMINES

PROBLEM TO BE SOLVED: To provide a method for producing bicyclic amines with improved yield thereof. SOLUTION: Provided is a method for producing bicyclic amine compounds represented by formula (1), which are hydroxyalkyltriethylenediamines, by subjecting a raw material composition to intramolecular dehydration in vapor phase in the presence of a solid catalyst, where a mixture of N-dihydroxypropylpiperazines and N,N'-bis(dihydroxypropyl)piperazines is used as the raw material composition and an inorganic oxide represented by formula (4) is used as the solid catalyst [R1 to R8 are each independently H, a C1-4 alkyl group, a hydroxy group, a hydroxymethyl group, or a C1-4 alkoxy group]. AlaMbPcOd (4) [M is an alkali metal or an alkaline earth metal; P is phosphorus; 0.001≤b/a≤0.5 (molar ratio); 0.01≤c/a≤0.5 (molar ratio); and d is a number which depends on the bonding states of respective atoms]. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

METHOD FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE HAVING IMPROVED HUE

PROBLEM TO BE SOLVED: To provide a production method which makes it possible to improve the hue of a cyclic alkanolamine such as a hydroxyalkyltriethylenediamine and efficiently obtain a high-purity bicyclic compound. SOLUTION: A method for producing the bicyclic diamine includes bringing a crude hydroxyalkyltriethylenediamine reaction liquid comprising a hydroxyalkyltriethylenediamine represented by formula (1) into contact with oxygen at 110-170°C and then distilling and purifying it (R1-R10 independently represent H, a C1-4 alkyl group or a C1-4 hydroxyalkyl group). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

N - alkylpiperazine purification of

PROBLEM TO BE SOLVED: To provide a purification method of N-alkyl piperazines, capable of providing high purity N-alkyl piperazines with low cost and having a high recovery rate.SOLUTION: A mixture of N-alkyl piperazines and a piperazine is distilled in the presence of a polar organic solvent having a higher boiling point than that of the piperazine.

The method of manufacturing the amine compound Bicylic

PROBLEM TO BE SOLVED: To provide a method for simply obtaining a bicyclic amine compound at high yield and for suppressing by-product tar contents that may obstruct the continuous production. SOLUTION: The compound indicated by a formula (1) is subjected to intramolecular dehydration in a gas phase under the presence of a solid catalyst to produce the bicyclic amine compound indicated by a formula (2). In the formula (1), R1-R8each independently represents a hydrogen atom, a 1-4C alkyl group, a hydroxy group, a hydroxymethyl group or a 1-4C alkoxy group; X represents a carbon atom or a nitrogen atom; and Y represents a hydrogen atom, an alkyl group, a hydroxy group or a 1-4C hydroxyalkyl group. In the formula (2), R1-R8, X and Y are defined in the same manner as above. COPYRIGHT: (C)2012,JPOandINPIT

Method for producing N-alkylpiperazine

PROBLEM TO BE SOLVED: To provide a method for producing N-alkyl piperazines in high yield by selectively alkylating one amino group.SOLUTION: In the method for producing N-alkyl piperazines, piperazines represented by general formula (1) are reacted with a specific alkylating agent in the presence of an acid. In the formula: R-Rare each independently a hydrogen atom, a methyl group, an ethyl group, a 3-8C linear alkyl group or the like, a hydroxyethyl group, a hydroxypropyl group, a dihydroxypropyl group, a methoxy group, an ethoxy group, a phenyl group, a benzyl group, a 2-phenylethyl group, or the like.

METHOD FOR PRODUCING N-MONOSUBSTITUTED PIPERAZINE

PROBLEM TO BE SOLVED: To provide a method for producing N-monosubstituted piperazine selectively with high productivity and high yields. SOLUTION: An electrophilic reagent and an alkali source are added to a solution comprising piperazine, which has been heated at 70-90°C, to make a reaction occur therebetween, so that an addition ratio of the electrophilic reagent to the piperazine is 0.2-0.7 mole and an addition amount rate of the electrophilic reagent exceeds an addition amount rate of the alkali source. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

METHOD FOR PRODUCING BICYCLIC AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method for producing a bicyclic amine compound, in which the bicyclic amine compound, that is useful for pharmaceutical/agrochemical intermediates, catalysts for organic synthesis, chemical adsorbents, antibacterial agents or the like, is produced industrially, continuously and stably. SOLUTION: The method for producing the bicyclic amine compound shown by formula (2) (in which R1 to R10 are each H, a 1-4C alkyl group, a 1-4C hydroxyalkyl group or a hydroxyl group independently; any one of R9 and R10 is a 1-4C hydroxyalkyl group; X is C or C) by an intramolecular dehydration reaction of piperazine, the para position hydrogen of which is replaced by a 1-4C hydroxyalkyl group, or a piperidine derivative in the presence of a solid catalyst in a gas phase. When the intramolecular dehydration reaction is performed, a liquid raw material is used, which material contains a cyclic amine compound having a dihydroxyalkyl group and has 3 mg-O2/L dissolved oxygen concentration. COPYRIGHT: (C)2015,JPO&INPIT

METHOD OF PRODUCING BICYCLIC AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a method of efficiently producing a bicyclic amine compound while improving a color tone of it. SOLUTION: A method of producing a bicyclic amine compound includes a reaction step in which the formula (1) is made to react in a gas phase in the presence of a solid catalyst such as an inorganic oxide and a metal phosphoric acid, to produce a bicyclic amine compound of the formula (2), and a distillation step. COPYRIGHT: (C)2015,JPOandINPIT

NOVEL CYCLIC AMINE COMPOUND, AND PROCESS FOR PRODUCING POLYURETHANE RESIN USING SAME

To provide a novel cyclic amine compound and a process for producing a polyurethane resin by using it. A3-hydroxy-1,5-diazabicyclo[3.2.2]nonane represented by the following formula (1), and a process for producing a polyurethane resin by using a catalyst for producing a polyurethane resin, which contains the 3-hydroxy-1,5-diazabicyclo[3.2.2]nonane. When the compound represented by the formula (1) has optical isomers, diastereomers or geometric isomers, the compound includes both a mixture of any of them and an isolated isomer of any of them. [in the above formula (1), each of R1, R2, R3, R4, R5, R6, R7 and R8 which are independent of one another, is a hydrogen atom, a C1-4 alkyl group, a hydroxy group, a hydroxymethyl group or a C1-4 alkoxy group.]

PROCESS FOR PRODUCING HYDROXYALKYLTRIETHYLENEDIAMINE COMPOUND, AND CATALYST COMPOSITION FOR THE PRODUCTION OF POLYURETHANE RESIN USING THE HYDROXYALKYLTRIETHYLENEDIAMINE COMPOUND

To provide a process for producing a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine simply and in a small number of steps without requiring multistage reaction steps; a novel catalyst composition whereby a polyurethane product can be obtained with good productivity and good moldability without bringing about odor problems or environmental problems; and a process for producing a polyurethane resin using the catalyst composition. For example, a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine is produced by subjecting a mono-substituted dihydroxyalkylpiperazine and/or a di-substituted hydroxyalkylpiperazine to an intramolecular dehydration condensation reaction in the presence of an acid catalyst. Further, for example, a polyurethane resin is produced by using a catalyst composition which comprises a hydroxyalkyltriethylenediamine or hydroxytriethylenediamine (A), and an amine compound (B) having, in its molecule, one or more substituents selected from the group consisting of a hydroxy group, a primary amino group and a secondary amino group, or a tertiary amine compound (C) having a value of [blowing reaction rate constant/gelling reaction rate constant] of at least 0.5.