76950-43-1

Basic information

• Product Name: 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane
• Synonyms: 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane
• CAS NO: 76950-43-1
• Molecular Weight: 142.201
• Mol File: 76950-43-1.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 280℃ at 101.5kPa
• Density: 1.21 at 20℃
• CAS DataBase Reference: 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane(76950-43-1)
• EPA Substance Registry System: 2-hydroxymethyl-1,4-diazabicyclo<2.2.2>octane(76950-43-1)

Safety Data

• Hazardous Substances Data: 76950-43-1(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 96-13-9 2,3-Dibromopropan-1-ol 
• 616-23-9 2,3-Dichloro-1-propanol 
• 556-52-5 oxiranyl-methanol 
• 111-40-0 3-azapentane-1,5-diamine 
• 7483-59-2 1-(2,3-dihydroxy propyl)piperazine 
• 29924-70-7 2-carbethoxy-1,4-diazabicyclo<2.2.2>octane 
• 1198308-40-5 1-(2-hydroxyethyl)-3-hydroxymethylpiperazine 
• 1198308-39-2 diethyl 2-(piperazin-1-yl)malonate 
• 78531-48-3 N-(α-hydroxymethyl-β-hydroxyethyl)piperazine 
• 122323-85-7 (1,4-Dinitroso-piperazin-2-yl)-methanol 
• 78336-12-6 (1,4-Diamino-piperazin-2-yl)-methanol 
• 29924-68-3 methyl 1,4-diazabicyclo<2.2.2>octane-2-carboxylate 
• 76950-41-9 2-benzyloxymethyl-1,4-diazabicyclo<2.2.2>octane dihydrochloride 

Downstream Products

• 120340-35-4 2-acetoxymethyl-1,4-diazabicyclo<2.2.2>octane 

Relevant articles and documents

Method for synthesizing hydroxylalkyltriethylenediamine compound

The invention relates to a method for synthesizing a hydroxylalkyltriethylenediamine compound. The method comprises the steps of taking solid phosphorylated graphene (PGO) as a catalyst, adding a monosubstituted dihydroxylalkyl piperazine derivative and any of polar solvents with a dielectric constant greater than 10 into a reaction vessel, heating the temperature of the reaction vessel to 100 DEGC to 300 DEG C in a nitrogen gas atmosphere, carrying out a reaction for 1 to 5 hours with stirring under a reaction vessel pressure of 1 MPa to 10 MPa, cooling the temperature of the reaction vesselto 30 DEG C to 60 DEG C, then, subjecting the catalyst and a reaction solution to centrifugation, and subjecting the reaction solution to rectification under vacuum, thereby obtaining the product, i.e., the hydroxylalkyltriethylenediamine compound represented by a formula (I) shown in the description. According to the method, the process is simple, and the catalyst can be cyclically regenerated.In a synthesis process for 2-hydroxymethyl triethylenediamine, the conversion ratio of a reactant, i.e., dihydroxylalkyl piperazine can reach 95% or more, and the selectivity of the product, i.e., the2-hydroxymethyl triethylenediamine can reach 90% or more.

PRODUCTION METHOD FOR BICYCLIC AMINE COMPOUND

PROBLEM TO BE SOLVED: To provide a production method for obtaining bicyclic amine compounds with high reaction yield. SOLUTION: The method includes subjecting a hydroxyl group-containing cyclic amine compound of a formula (1) to intramolecular dehydration in a gas phase in the presence of a solid catalyst containing alkaline earth metal phosphate and alkali metal salt [in the formula (1), R1 to R8 each independently represent a hydrogen atom, a C1 to 4 alkyl group, a hydroxy group, a hydroxymethyl group, or a C1 to 4 alkoxy group; X represents a carbon atom or a nitrogen atom; Y represents an alkyl group, a hydroxy group, a C1 to 4 hydroxyalkyl group, or a C1 to 4 aminoalkyl group]. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

METHOD FOR PRODUCING CYCLIC AMINES

PROBLEM TO BE SOLVED: To provide a method for efficiently producing cyclic amines. SOLUTION: The present invention provides a method for producing cyclic amines represented by formula (2), including subjecting alkanolamines to cyclodehydration in the presence of a solid catalyst containing at least one selected from titanium oxide, silicon oxide, and zirconium oxide (R3-R10 independently represent H, C1-4 alkyl, a hydroxy group, hydroxymethyl or C1-4 alkoxy; X is C or N; Y is alkyl, a hydroxy group, C1-4 hydroxyalkyl or C1-4 aminoalkyl). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT