7484-41-5

Basic information

• Product Name: 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-4-[(phenylmethylene)amino]-3-thioxo-
• CAS NO: 7484-41-5
• Molecular Formula: C11H10N4OS
• Molecular Weight: 246.293
• Mol File: 7484-41-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-4-[(phenylmethylene)amino]-3-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-4-[(phenylmethylene)amino]-3-thioxo-(7484-41-5)
• EPA Substance Registry System: 1,2,4-Triazin-5(2H)-one, 3,4-dihydro-6-methyl-4-[(phenylmethylene)amino]-3-thioxo-(7484-41-5)

Safety Data

• Hazardous Substances Data: 7484-41-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 22278-81-5 4-amino-5-oxo-3-thioxo-6-methyl-2,3,4,5-tetrahydro<1,2,4>triazine 
• 22278-81-5 4-amino-6-methyl-3-thio-1,2,4-triazin-5-one 

Downstream Products

• 918165-78-3 (S)-4-(1-phenylpropyl)amino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-one 
• 851053-39-9 3-methyl-7-phenyl-1H-pyrazolo[5,1-c][1,2,4]triazin-4-one 
• 1329018-96-3 8-benzoyl-3-methyl-7-phenyl-1H-pyrazolo[5,1-c][1,2,4]triazin-4-one 
• 89988-50-1 1-(benzylideneamino)-3-methyl-2H-<1,2,4>triazino<3,2-b>quinazoline-2,6(1H)-dione 
• 20306-86-9 (S)-N-(1-phenylpropyl)acetamide 
• 89988-36-3 4-(benzylideneamino)-3-(methylthio)-6-methyl-1,2,4-triazin-5(4H)-one 
• 3789-59-1 (R)-1-phenylpropylamine 

Relevant articles and documents

Stereoselective synthesis of dihydrothiadiazinoazines and dihydrothiadiazinoazoles and their pyrolytic desulfurization ring contraction

Intramolecular base catalyzed C-C bond formation led to exclusive stereoselective syntheses of trans-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazines, trans-7,8-dihydro-6H-[1,2,4]triazino[3,4-b][1,3,4]thiadiazin-4- ones, and trans-3,4-dihydro-2H-

Enantioselective diethylzinc addition to the exocyclic C{double bond, long}N double bond of some 4-arylideneamino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-one derivatives

4-Arylideneamino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-ones 2a-f have been evaluated as substrates in the enantioselective diethylzinc addition reaction in the presence of (1S,2R)-N-alkyl-N-benzylnorephedrines 3a-d as chiral ligands. The utility of using a dual catalytic system (amino alcohol/halosilane) for the diethylzinc addition reaction has been also examined. The addition products 4-(1-arylpropyl)amino-3-mercapto-6-methyl-4H-1,2,4-triazin-5-ones 4a-f were obtained in high yields and with enantiomeric excesses of up to 92%. The treatment of arylimines 2a-f with a diethylzinc reagent did not affect the hetero-ring opening although the C{double bond, long}N double bond of the lateral chain did undergo an addition reaction to yield the C-ethylated products 4a-f. The reductive cleavage of the 1,2,4-triazinyl heterocyclic ring from addition products 4a-f led smoothly to the corresponding free primary amines 5a-f without a significant loss of enantiomeric purity.

Synthesis and Structure of as-Triazinoquinazolines, II.

4-Amino-3-(methylthio)-6-R-1,2,4-triazin-5(4H)-ones 6-10 react with anthranilic acid to yield the 1-amino-3-R-2H-as-triazinoquinazoline-2,6(1H)-diones 17-21 rather than the expected as-triazinobenzotriazepines 12-16.Compounds 17-21 were deaminated into compounds 22-26.Heating of the N-benzylidene derivatives of 6-10 (27-31) with anthranilic acid also led to the formation of 22-26 with extrusion of benzonitrile.