89988-50-1

Upstream product

• 118-92-3 anthranilic acid 
• 89988-36-3 4-(benzylideneamino)-3-(methylthio)-6-methyl-1,2,4-triazin-5(4H)-one 
• 100-52-7 benzaldehyde 
• 89988-40-9 1-amino-3-methyl-2H-<1,2,4>triazino<3,2-b>quinazoline-2,6(1H)-dione 
• 7484-41-5 4-(benzylideneamino)-3,4-dihydro-6-methyl-3-thioxo-1,2,4-triazin-5(2H)-one 

Downstream Products

• 100-47-0 benzonitrile 
• 89988-45-4 3-methyl-2H-<1,2,4>triazino<3,2-b>quinazoline-2,6(1H)-dione 

Relevant academic research and scientific papers

Synthesis, characterization, and biological activity of some aza-uracil derivatives

Thiation of 1 by LR gave the corresponding 3,5-dithioxo derivative 2 and the trimer 3. Methylation of 1 afforded the S-methyl derivative 4. Compound 1 was fused with 6-bromo-2-phenyl-benzo[1,3-d]oxazin-4-one (5) and gave 6. Condensation of 1 with some acid derivatives 7a-d and/or 8a-c yielded thiadiazolo-triazine derivatives 9a-d and 10a-c. Compounds 9a,c and 10c were hydrolyzed to furnish 11a-c. Acetylation of 14 afforded mono- and diacetyl-derivatives 15 and 16. Benzoylation of 14 afforded mono- and dibezoyl-derivatives 17 and 18. 14 with some aromatic aldehydes yielded 19a-c. Reacting 14 with phenyl (iso- and/or isothio-) cyanate gave the urea derivatives 20a,b. Thiation of 14 with P4S10 furnished 21. The newly synthesized compounds were tested as antimicrobial agents.

Synthesis and Structure of as-Triazinoquinazolines, II.

4-Amino-3-(methylthio)-6-R-1,2,4-triazin-5(4H)-ones 6-10 react with anthranilic acid to yield the 1-amino-3-R-2H-as-triazinoquinazoline-2,6(1H)-diones 17-21 rather than the expected as-triazinobenzotriazepines 12-16.Compounds 17-21 were deaminated into compounds 22-26.Heating of the N-benzylidene derivatives of 6-10 (27-31) with anthranilic acid also led to the formation of 22-26 with extrusion of benzonitrile.