7486-94-4

Basic information

• Product Name: 4-ethenylazetidin-2-one
• CAS NO: 7486-94-4
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.1152
• Mol File: 7486-94-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 236.5°C at 760 mmHg
• Flash Point: 124.1°C
• Density: 1.151g/cm³
• Vapor Pressure: 0.0472mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 4-ethenylazetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ethenylazetidin-2-one(7486-94-4)
• EPA Substance Registry System: 4-ethenylazetidin-2-one(7486-94-4)

Safety Data

• Hazardous Substances Data: 7486-94-4(Hazardous Substances Data)

Upstream product

• 1189-71-5 isocyanate de chlorosulfonyle 
• 106-99-0 buta-1,3-diene 
• 22937-11-7 2-oxo-4-vinyl-azetidine-1-sulfonyl chloride 
• 1826-67-1 vinyl magnesium bromide 
• 90497-61-3 4-(phenylsulfonyl)-2-azetidinone 
• 28562-53-0 4-acetoxy azetidinone 
• 917-57-7 vinyllithium 

Downstream Products

• 40156-34-1 1-methyl-4-vinyl-azetidin-2-one 
• 160291-26-9 4-[2-(4-methoxyphenyl)-vinyl]-azetidin-2-one 
• 78687-70-4 2-Allyl-2-(2-oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78687-68-0 2-Chloro-2-(2-oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78687-69-1 2-(2-Oxo-4-vinyl-azetidin-1-yl)-malonic acid bis-(4-nitro-benzyl) ester 
• 78840-77-4 1-(p-nitrobenzyl) 4-ethyl 2-(2-oxo-4-vinylazetidin-1-yl)-3-(triphenylphosphoranylidene)succinate 
• 78840-76-3 1-t-butyl 4-ethyl 2-(2-oxo-4-vinylazetidin-1-yl)-3-(triphenylphosphoranylidene)-succinate 
• 76131-73-2 p-nitrobenzyl α-chloro-α-(2-oxo-4-vinylazetidin-1-yl)-acetate 
• 80241-98-1 diphenyl-t-butylsilyl-(7aRS,7bRS)-6,7,7a,7b-tetrahydro-3-methyl-6-oxo-1H-azeto<1,2-a>azirino<2,1-c>pyrazine-4-carboxylate 
• 103723-45-1 1-(1-diphenyl-t-butylsilyloxycarbonyl-2-hydroxyprop-1-enyl)-4-vinylazetidin-2-one 
• 103723-44-0 C₂₃H₂₇NO₃Si 
• 86039-84-1 (3R,4S)-3-(Hydroxy-phenyl-methyl)-1-pyrrolidin-1-ylmethyl-4-vinyl-azetidin-2-one 
• 54287-61-5 (3R,4S)-3-(Hydroxy-diphenyl-methyl)-4-vinyl-azetidin-2-one 
• 86039-85-2 (3R,4S)-3-(Hydroxy-phenyl-methyl)-4-vinyl-azetidin-2-one 

Relevant articles and documents

Intramolecular azide to alkene cycloadditions for the construction of pyrrolobenzodiazepines and azetidino-benzodiazepines

The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing pyrr

A concise synthesis of β-lactam-sulfonamide hybrids

Using ring closing metathesis (RCM) as the key operation, a rapid access to β-lactams fused to a sultam moiety of variable ring size was developed from low cost, commercially available starting materials. An efficient RCM of 4-vinyl-azetidin-2-ones to give 1-aza-bicyclo[4.2.0]oct-4-en-8-ones is also reported.

Synthesis of 3-amino-3-vinylpropanoic acid and its conversion to 4-amino-5-hydroxy-4,5-dihydrofuran-2-one hydrochloride (HAD), a cyclic stabilised form of aspartate 1-semialdehyde hydrochloride

3-amino-3-vinylpropanoic acid hydrochloride 4 was obtained from 4-acetoxyazetidin-2-one 1 in 3 steps. The ozonolysis of 4 yielded 3-amino-4-oxopropanoic acid hydrochloride (aspartate 1-semialdehyde hydrochloride 6). This labile α-aminoaldehyde is isolated