7486-94-4

Upstream product

• 28562-53-0 4-acetoxy azetidinone 
• 917-57-7 vinyllithium 
• 1826-67-1 vinyl magnesium bromide 
• 90497-61-3 4-(phenylsulfonyl)-2-azetidinone 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 106-99-0 buta-1,3-diene 
• 22937-11-7 2-oxo-4-vinyl-azetidine-1-sulfonyl chloride 

Downstream Products

• 124033-84-7 (Z)-5-Phenyl-3-pentenamide 
• 124033-83-6 (E)-5-Phenyl-3-pentenamide 
• 148059-06-7 (Z)-5-(2-Methoxy-phenyl)-pent-3-enoic acid amide 
• 148058-99-5 (E)-5-(2-Methoxy-phenyl)-pent-3-enoic acid amide 
• 114463-00-2 t-butyl α-hydroxy-α-(2-oxo-4-vinylazetidin-1-yl)acetate 
• 78840-75-2 t-butyl α-chloro-α-(2-oxo-4-vinylazetidin-1-yl)acetate 
• 148059-07-8 4-((Z)-4-Carbamoyl-but-2-enyl)-benzoic acid ethyl ester 
• 148059-00-1 4-((E)-4-Carbamoyl-but-2-enyl)-benzoic acid ethyl ester 
• 76131-72-1 p-nitrobenzyl α-hydroxy-α-(2-oxo-4-vinylazetidin-1-yl)-acetate 
• 103564-07-4 4-(trans-2-phenylethenyl)azetidin-2-one 
• 160291-18-9 (E)-5-Phenyl-pent-3-enoic acid amide 
• 74694-48-7 4(S)-4-hydroxymethyl azetidin-2-one 
• 40156-34-1 1-methyl-4-vinyl-azetidin-2-one 
• 79669-45-7 1-4-vinylazetidin-2-one 

Relevant academic research and scientific papers

Intramolecular azide to alkene cycloadditions for the construction of pyrrolobenzodiazepines and azetidino-benzodiazepines

The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing pyrr

Convergent synthesis of (2R,3R,8R,9R)-N-Boc-ADDA

(Figure Presented) The convergent synthesis of N-Boc-(2R,3R,8R,9R,4E,6E)-3- amino-9-methoxy-2,6,8-trimethyl-10-phenyldecadenoic acid (enantio-N-Boc-ADDA) is reported. Our flexible approach takes advantage of highly efficient non-aldol aldol and cross-metathesis methodologies.

A concise synthesis of β-lactam-sulfonamide hybrids

Using ring closing metathesis (RCM) as the key operation, a rapid access to β-lactams fused to a sultam moiety of variable ring size was developed from low cost, commercially available starting materials. An efficient RCM of 4-vinyl-azetidin-2-ones to give 1-aza-bicyclo[4.2.0]oct-4-en-8-ones is also reported.

2-CYANOPYRROLES AND THEIR ANALOGUES AS DDP-IV INHIBITORS

The present invention relates to therapeutically active and selective inhibitors of the enzyme DPP-IV having the formula I: (I) The invention furthermore relates to pharmaceutical compositions comprising the compounds and the use of such compounds for the manufacture of medicaments for treating diseases that are associated with proteins which are subject to inactivation by DPP-IV, such as type 2 diabetes and obesity.

Synthesis of 3-amino-3-vinylpropanoic acid and its conversion to 4-amino-5-hydroxy-4,5-dihydrofuran-2-one hydrochloride (HAD), a cyclic stabilised form of aspartate 1-semialdehyde hydrochloride

3-amino-3-vinylpropanoic acid hydrochloride 4 was obtained from 4-acetoxyazetidin-2-one 1 in 3 steps. The ozonolysis of 4 yielded 3-amino-4-oxopropanoic acid hydrochloride (aspartate 1-semialdehyde hydrochloride 6). This labile α-aminoaldehyde is isolated

A Superior Procedure for the Preparation of 2-Azetidinones From Volatile Olefins

The use of a pressure bottle for cycloaddition of chlorosulfonyl isocyanate with volatile olefins not only provides the azetidinones in significantly improved yield, but also greatly simplifies the experimental procedure.

SYNTHESIS OF 4-SUBSTITUED 2-AZETIDIONES

4-Substitued 2-azetidiones were obtained in excellent yields from the reaction of various cuprates with 4-acetoxy-2-azetidinone.

3-Substituted-6-substituted-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

Disclosed are 3- and 6-substituted 7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: STR1 wherein R6, R7 and R8 are, inter alia, independently selected from the group consisting of hydrogen, alky

A New Method for the Carbon-extension Reactions of Azetidin-2-ones at the 4-Position

High yields of 4-alkyl-, 4-allyl-, 4-vinyl-, or 4-ethynynl-azetidin-2-ones are obtained by treating 4-sulphonylazetidin-2-ones with either lithium organocuprates or Grignard reagents, but yields from 4-acetoxyazetidin-2-one with Grignard reagents are low.