748764-57-0

Basic information

• Product Name: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole
• Synonyms: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole
• CAS NO: 748764-57-0
• Molecular Weight: 388.288
• Mol File: 748764-57-0.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole(748764-57-0)
• EPA Substance Registry System: 2-(2-(4-bromobenzylidene)hydrazinyl)-4-(4-methoxyphenyl)thiazole(748764-57-0)

Safety Data

• Hazardous Substances Data: 748764-57-0(Hazardous Substances Data)

Upstream product

• 36449-43-1 2-(4-bromobenzylidene)hydrazine carbothioamide 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 1122-91-4 4-bromo-benzaldehyde 
• 1629144-43-9 2-phenoxy-4-(4-methoxyphenyl)thiazole 

Relevant articles and documents

One PotTwo Step Synthesis of 2-Arylidenehydrazinyl-4-arylthiazole

An efficient, simple one pot, two step procedure has been developed for the synthesis of 2-arylidenehydrazinyl-4-arylthiazole. The reaction of aromatic aldehyde, thiosemicarbazide and phenacyl bromide gave the desired products in good yield. The first reaction product thiosemicarbazone was obtained on reaction with aromatic aldehyde and thiosemicarbazide; without isolating this directly treated with phenacyl bromide in presence of acidic buffer at room temperature desired product was obtained with simple workup procedure.

2,4- and 2,5-disubstituted arylthiazoles: Rapid synthesis by C-H coupling and biological evaluation

Life-threatening infections caused by bacteria that have developed resistance to common antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA), have become a serious problem in hospitals and other areas all over the world. Thus, the development of an effective class of antibiotics against these bacteria is an urgent subject. Herein, we report a step-economical and diversity-oriented synthesis of a series of 2-arylidenehydrazinyl-4- arylthiazole and 2-arylidenehydrazinyl-5-arylthiazole analogues that utilizes C-H coupling methodologies. A library of 54 new congeners were synthesized and tested for their biological potential. Moreover, new knowledge regarding the structure-activity relationships (SARs) of these heterobiaryl compounds was collected. Copyright