74879-19-9Relevant articles and documents
1-arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor
Ukita, Tatsuzo,Nakamura, Yoshinori,Kubo, Akira,Yamamoto, Yasuo,Takahashi, Masami,Kotera, Jun,Ikeo, Tomohiro
, p. 1293 - 1305 (2007/10/03)
1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan s
Hydroxyacetals, phtalans, and isobenzofurans therefrom
Keay, Brian A.,Plaumann, Heinz P.,Rajapaksa, Dayananda,Rodrigo, Russell
, p. 1987 - 1995 (2007/10/02)
A general method for the generation of isobenzofuran intermediates is described.Lithiated aromatic acetals are converted to hydroxyacetals (A) which may be cyclized to isobenzofurans by mild acid treatment through the 1-hydroxyphtalans (B).The isobenzofur