74897-48-6Relevant articles and documents
Design, synthesis and biological evaluation of novel indole-based oxalamide and aminoacetamide derivatives as tubulin polymerization inhibitors
Chen, Peng,Diao, Peng-Cheng,Huang, Chuan,Huang, Jie Chun,Jian, Xie-Er,Li, Jun-Sheng,Yin, Jie,Zhao, Pei-Liang
, (2019/11/28)
A series of novel indole-based oxalamide and aminoacetamide derivatives were designed, synthesized, and evaluated for antiproliferative activities. Preliminary results revealed that compound 8g exhibited significant antiproliferative effect against PC-3,
Tricyclic Systems Obtained from Some 3-Aminobenzothiophen Derivatives
Clarke, Kenneth,Fox, William Richard,Scrowston, Richard M.
, p. 833 - 847 (2007/10/02)
4-Hydroxybenzothienopyridin-2(1H)-one (3) was obtained by cyclisation of a benzothiophen derivative containing either 2-CO2Et, 3-NH.CO.CH2.CO2Et or 2-CO.CH2.CO2Et, 3-NH2 substituents. 3-Amino-2-formyl-, 3-amino-2-acetyl-, and 3-amino-2-acetyl-5-nitro-benzothiophens were converted into the corresponding 3-thiocyanato-compounds, which gave tricyclic systems when treated with hydroxylamine.Heating these with polyphosphoric acid gave benzothienoisothiazole, and its 3-methyl and 3-methyl-7-nitro-derivatives respectively.Nitration, formylation, and oxidation reactions of 3-methylbenzothienoisothiazole have been investigated.
