7491-86-3

Usage

InChI:InChI=1/C15H10N2O2/c18-15(19)11-9-14(13-7-3-4-8-16-13)17-12-6-2-1-5-10(11)12/h1-9H,(H,18,19)/p-1

Upstream product

• 21948-75-4 2-methylsulfinylpyridine 
• 21948-80-1 methyl 2-quinolyl sulfoxide 
• 2005-43-8 2-bromoquinoline 
• 17997-47-6 2-tri-n-butylstannylpyridine 

Downstream Products

• 75-05-8 acetonitrile 
• 1613512-45-0 C₃₃H₄₅N₂PPt 
• 1443500-50-2 [Pt(2-(2′-pyridyl)quinoline(-H))(Cl)(PPh₃)] 
• 1443500-54-6 [Pt(2-(2′-pyridyl)quinoline(-H))(Me)(PPh₃)] 

Relevant academic research and scientific papers

TRICYCLIC HETEROCYCLES AS BET PROTEIN INHIBITORS

The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment of diseases such as cancer.

Heteroaryl cross-coupling as an entry toward the synthesis of lavendamycin analogues: A model study

(Chemical Equation Presented) ABC analogues of the antitumor antibiotic lavendamycin, which contain the key metal chelation site and redox-active quinone unit essential for biological activity, were prepared via the palladium(0)-catalyzed cross-coupling reaction of various 2-haloheteroaromatics with 2-stannylated pyridines and quinolines. Using the Stille reaction, 2-bromo substituted quinolines and 1-bromoisoquinolines were found to undergo efficient coupling with 2-pyridinylstannanes to provide unsymmetrical heterobiaryl derivatives. While the Stille reaction using the reverse coupling partners (i.e., 2-quinolinylstannanes and haloheteroaromatics) had not received much attention in the literature, we found that this alternative coupling reaction efficiently provided several new heterobiaryl derivatives. The gold-catalyzed intramolecular cycloisomerization of N-(prop-2-ynyl)-1H-indole-2-carboxamide smoothly afforded a β-carbolinone derivative that was subsequently used for a Pd(0)-catalyzed cross-coupling directed toward the synthesis of lavendamycin analogues.