195137-95-2

Basic information

• Product Name: (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one
• Synonyms: (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one;2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylcarbonyl)-, (S)-
• CAS NO: 195137-95-2
• Molecular Formula: C₁₇H₁₅NO₂
• Molecular Weight: 265.3065
• EINECS: -0
• Mol File: 195137-95-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one(195137-95-2)
• EPA Substance Registry System: (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one(195137-95-2)

Safety Data

• Hazardous Substances Data: 195137-95-2(Hazardous Substances Data)

Usage

General Description

(S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one is a chemical compound that belongs to the category of pyrrolidones. Its molecular formula is C20H19NO2 and its molecular weight is 309.37 g/mol. (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one has a bicyclic structure, with a pyrrolidin-2-one ring attached to a biphenyl-4-ylcarbonyl group. It is often used in pharmaceutical research and drug development due to its potential as a building block in the synthesis of various biologically active compounds. It also possesses potential pharmacological properties, including its ability to interact with specific biological targets. As a result, (S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one has attracted attention as a potential drug candidate for various therapeutic applications.

Upstream product

• 85187-29-7 (S)-5-(morpholine-4-carbonyl)pyrrolidin-2-one 
• 92-52-4 biphenyl 
• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 
• 3315-91-1 4-biphenylylmagnesium bromide 
• 51959-85-4 (R/S)-5-(morpholine-4-carbonyl)pyrrolidin-2-one 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 7439-95-4 magnesium 
• 77-92-9 citric acid 

Downstream Products

• 1038924-77-4 (S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid tert-butyl ester 
• 1038924-61-6 (S)-5-biphenyl-4-ylmethylpyrrolidin-2-one 

Relevant articles and documents

A Entresto intermediate (S)- 5 - (biphenyl - 4 - carbonyl) pyrrolidine - 2 - one synthetic method

The invention discloses a synthetic method of Entresto midbody (S)-5-(diphenyl-4-carbonyl) pyrrolidine-2-ketone. The synthetic method comprises the following steps: taking (S)-5-(morpholine-4-carbonyl) pyrrolidine-2-ketone and (chloromethyl) benzene as raw materials, dissolving in organic solvent, and obtaining (S)-1-benzyl-5-(morpholine-4-carbonyl) pyrrolidine-2-ketone under the action of alkali, then reacting with an organic solution of 4-diphenyl magnesium bromide, and carrying out the debenzylation reaction to generate the Entresto midbody (S)-5-(diphenyl-4-carbonyl) pyrrolidine-2-ketone. By adopting the synthetic method, the dosage of diphenyl magnesium bromide is remarkably reduced, so that the production cost is obviously reduced, and the production period is greatly shortened; during the process for manufacturing a diphenyl magnesium bromide Grignard reagent, the yield is relatively low. According to the synthetic method, due to the reduction of the dosage of the diphenyl magnesium bromide, the danger coefficient is also reduced (the production is safer). The synthetic method is more suitable for the industrialized production.

NEW PROCESS

-