7495-04-7Relevant academic research and scientific papers
A one-pot cross-pinacol coupling/rearrangement procedure
Scheffler, Ulf,Mahrwald, Rainer
, p. 1970 - 1975,6 (2012/12/12)
A new catalytic retro-pinacol/cross-pinacol reaction, followed by subsequent rearrangement or deoxygenation of the intermediately formed vicinal diols, is described. This operationally simple one-pot protocol allows isolation of geminal α,α-diphenyl ketones or 1,1-diphenyl alkenes with high yields and selectivities. Copyright
A synthesis of (S)-α-(fluorodiphenylmethyl)alkylamines by HF-pyridine treatment of 4-alkyl-5,5-diphenyl-oxazolidinones
O'Hagan, David,Royer, Frederique,Tavasli, Mustafa
, p. 2033 - 2036 (2007/10/03)
Treatment of enantiomerically pure (S)-4-alkyl-5,5-diphenyl-oxazolidinones, themselves derived from appropriate amino acids, with HF-pyridine (Olah's reagent) generated a range of (S)-α-(fluorodiphenylmethyl)alkylamines. These compounds represent a novel range of fluorinated chiral amines. Copyright (C) 2000 Elsevier Science Ltd.
Synthesis of 2,2-Diphenyl-3-oxetanol Derivatives and Their Thermal or Acid-catalyzed Decomposition
Shimizu, Nobujiro,Yamaoka, Shintaro,Tsuno, Yuho
, p. 3853 - 3854 (2007/10/02)
A series of five different 2,2-diphenyl-3-oxetanols was synthesized by photocycloadditiion of benzophenone and enol trimethylsilyl ethers followed by protolysis of the resultant 3-trimethylsiloxyoxetanes.Thermal cleavage and acid-catalyzed rearrangement of these oxetanes are described.
Dianions Derived from α-Halo Acids. The Darzens Condensation Revisited
Johnson, Carl R.,Bade, Thomas R.
, p. 1205 - 1212 (2007/10/02)
The dianions of α-halo carboxylic acids are readily generated by the addition of the acids to 2 equiv of lithium diisopropylamide at low temperatures.When the mixture warms to room temperature dimeric products are formed.When aldehydes and ketones were added to the cooled solutions of the dianions and the reaction mixtures were allowed to warm to room temperature, followed by acid quench, glycidic acids were formed.The glycidic acids, per se, were often too unstable to be isolated and purified but could be analyzed by conversion to their methyl esters withdiazomethane.When the reactions were quenched prematurely, α-chloro-β-hydroxy carboxylic acids were isolated.Homologated aldehydes and ketones were obtained from the glycidic acids by catalytic and thermal decarboxylation methods.
