7495-75-2

Upstream product

• 75-15-0 carbon disulfide 
• 109-73-9 N-butylamine 

Downstream Products

• 121216-05-5 3-Butyl-6-(4-nitro-phenyl)-2-thioxo-[1,3]thiazinan-4-one 
• 64220-73-1 5-(3-butyl-4-hydroxy-2-thioxo-thiazolidin-4-yl)-2-chloro-benzenesulfonamide 
• 21035-72-3 (+)-cis-1,3-dibenzyl-hexahydro-1H-thieno[3,4-d]imidazole-2,4-dione 
• 121215-99-4 3-Butyl-6-(4-methoxy-phenyl)-2-thioxo-[1,3]thiazinan-4-one 
• 121216-13-5 3-Butyl-6-phenyl-2-thioxo-[1,3]thiazinan-4-one 
• 92442-01-8 β--propionsaeure 

Relevant academic research and scientific papers

2,2′-Bipyridinebutyldithiocarbamatoplatinum(II) and palladium(II) complexes: Synthesis, characterization, cytotoxicity, and rich DNA-binding studies

Butyldithiocarbamate sodium salt (Bu-dtcNa) and its two complexes, [M(bpy)(Bu-dtc)]NO3 (M = Pt(II) or Pd(II) and bpy = 2,2′-bipyridine), have been synthesized and characterized on the basis of elemental analysis, molar conductivities, IR, 1H NMR, and UV-vis spectra. In these complexes, the dithiocarbamato ligand coordinates to Pt(II) or Pd(II) center as bidentate with two sulfur atoms. These complexes show 50% cytotoxic concentration (Cc50) values against chronic myelogenous leukemia cell line, K562, much lower than that of cisplatin. The interaction of these complexes with calf thymus DNA was extensively investigated by a variety of spectroscopic techniques. These studies showed that both complexes presumably intercalate in DNA. UV-vis studies imply that they cooperatively bind with DNA and unexpectedly denature the DNA at very low concentrations (～100 μL). Palladium complex breaks the DNA into two unequal fragments and binds stronger to the lighter fragment than to the heavier one. In the interaction studies between the Pt(II) and Pd(II) complexes with DNA, several binding and thermodynamic parameters have been determined, which may provide deeper insights into the mechanism of action of these types of complexes with nucleic acids.

Synthesis of potential plant protecting compounds on the basis of 2,3-dihydrothiazol-2-thione. I. Change in structure at the N3 and C4

A considerable number of potential plant protecting compounds with the core structure of 2,3-dihydrothiazol-2-thione has been prepared by the reaction of dithiocarbamates with halomethylcarbonyl compounds forming N-substituted 4-substituted 4-hydroxythiazolidin-2-thiones 2-4, which can split off water to yield 5. The structural variability at N3 is given either by the amine used for dithiocarbamate synthesis or by acylation of N-unsubstituted 2,3-dihydrothiazol-2-thiones like 4i. The variability at C4 is either achieved by the kind of the halomethylcarbonyl compound or by reactions of 4:chloromethyl derivatives 5, which can be transformed by a number of nucleophilic reagents to derivatives like thioethers 8, ethers 9, amines 10, nitriles 11, azides 12a, thiocyanates 12b, the primary amine 14 and derived from that the amides 15 or the ureas 16. Wiley-VCH Verlag GmbH, 2000.