7495-78-5Relevant academic research and scientific papers
3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION
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Page/Page column 84-85, (2014/04/04)
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using diaryloxindole compounds are described.
UV-vis absorption spectra of 1,4-dialkoxy-2,5-bis[2-(thien-2-yl)ethenyl]benzenes
Fuks-Janczarek,Reshak, Ali H.,Kuznik,Kityk,Gabanski,Lapkowski,Motyka,Suwinski
experimental part, p. 394 - 398 (2009/04/13)
Complex theoretical and experimental studies and quantum-chemical calculations were applied to study the UV-vis spectroscopic features of the novel compounds: three stereoisomers of 1,4-diethoxy-2,5-bis[2-(5-methylthien-2-yl)ethenyl]benzene (A-C) and E,E isomer of 1,4-diisopropoxy-2,5-bis[2-(thien-2-yl)ethenyl]benzene (D). These structures are the derivatives of 2,5-bis[2-(thien-2-yl)ethenyl]benzene, and belong to a group of thienyl-PPV family that are able to polymerize due to the presence of π-conjugated bonding system. It was established that such compounds during electropolymerization are strongly dependent on their stereochemistry and on the eventual presence of substituents in α-positions of the tiophene ring. We have obtained a good agreement between the theoretically simulated optical within a framework of TDDFT approach and experimentally measured data. Influence of PMMA polymer matrices on the UV-vis spectra is explored. It is shown that a red wavelength spectral shift is observed only for D compounds and agreement between calculated and experimental spectral data is sufficiently good. This may indicate on different influence of local polymer matrix field on the spectral behaviors of the chromophores with different stereochemistry.
Enantioselective hydride abstraction in organic substrates: A novel use for chiral carbenium ions
Magdziak, Derek,Pettus, Liping H.,Pettus, Thomas R. R.
, p. 557 - 559 (2007/10/03)
(Matrix presented) It is surprising that chiral cations have not been used to distinguish between prochiral hydrides when converse notions, such as asymmetric addition of a hyride to a prochiral functional group or use of a chiral anion to distinguish bet
Selective nitration versus oxidative dealkylation of hydroquinone ethers with nitrogen dioxide
Rathore,Bosch,Kochi
, p. 6727 - 6758 (2007/10/02)
Various alkyl-substituted p-dialkoxybenzenes (ArH) react readily with nitrogen dioxide (NO2) in dichloromethane solution via either nitration (ArNO2) or oxidative dealkylation to quinones (Q). Spectral transients indicate that these coupled processes proceed from the dialkoxybenzene radical cation (ArH+) formed as the common reactive intermediate from electron-transfer in the disproportionated precursor [ArH, NO+]NO3-. In fast subsequent steps, ArH+ undergoes homolytic coupling with NO2 (which leads to aromatic nitration) and nucleophilic attack of NO3- (which results in oxidative dealkylation). As such, the competition between nitration and oxidative dealkylation is effectively modulated by solvent polarity and added nitrate.
PHASE-TRANSFER NUCLEOPHILIC AROMATIC SUBSTITUTION OF Cr(CO)3-COMPLEXED DICHLOROBENZENES WITH ALCOHOLS
Alemagna, Andreina,Baldoli, Clara,Del Buttero, Paola,Licandro, Emanuela,Maiorana, Stefano
, p. 555 - 560 (2007/10/02)
Cr(CO)-complexed ortho- and para-dichlorobenzenes react with primary and secondary alcohols, in the presence of KOH, under phase-transfer conditions to give monosubstitution products only.The meta isomer affords disubstitution products also.The same reaction, carried out in DMSO with alcohols in excess, leads in all cases to dialkoxy derivatives.Factors potentially influencing the reactivity of Cr(CO)3-complexed ortho-, meta-, and para-dichlorobenzenes are discussed.
PHOSPHORORGANISCHE VERBINDUNGEN 101. TERTIAERE PHOSPHINE MIT ORTHOALKOXYPHENYL-GRUPPEN. Synthese und Eigenschaften
Horner, L.,Simons, G.
, p. 189 - 210 (2007/10/02)
Alkylphenylethers, ortho-lithiated in good yields, are transformed according to scheme (1) to the triarylphosphines ArPPh2, Ar2PPh and Ar3P (Ar contains in all cases an ortho-alkoxy group) (Table 1.).Hydroquinonedialkylethers can be lithiated twice, forming the compounds 102 and 103.Table 2 summarizes some arylalkylethers (71 - 101) which were lithiated; table 7 presents 12 new arylalkylethers.The syntheses of triarylphosphines with one or two bulky groups (105 - 110) and of triarylphosphines with one or two 3,4-dialkoxyphenyl groups (111 - 114) are reported.The 31P-spectra of the compounds prepared are discussed with respect to the validity of the Tolman-rule.
The Electrochemical Metoxylation of Dialkoxyaromatic Compounds and the Determination of Isomer Ratios by N.M.R. Spectroscopy
Elgy, Geraldine M.,Jennings, W. Brian,Pedler, Alan E.
, p. 1255 - 1260 (2007/10/02)
Electrolysis in methanol-KOH solution of p-diethoxy-, p-di-n-propoxy-, p-di-isopropoxy-, p-di-n-butoxy-, p-di-isobutoxy-, and p-di-s-butoxy-benzenes afforded the corresponding 3,6-dialkoxy-3,6-dimethoxy-cyclohexa-1,4-diene, shown by 1H n.m.r. spectroscopy to be an approximately equimolar mixture of cis- and trans-isomers.Likewise, from 9,10-diethoxyanthracene was obtained an equimolar mixture of the cis- and trans-isomers of 9,10-diethoxy-9,10-dimethoxy-9,10-dihydroanthracene.
