74959-64-1

Basic information

• Product Name: 4-methoxybenzaldehyde N-phenylthiosemicarbazone
• CAS NO: 74959-64-1
• Molecular Formula: C₁₅H₁₅N₃OS
• Molecular Weight: 285.3641
• Mol File: 74959-64-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 424.6°C at 760 mmHg
• Flash Point: 210.6°C
• Density: 1.16g/cm³
• Vapor Pressure: 2.04E-07mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 4-methoxybenzaldehyde N-phenylthiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methoxybenzaldehyde N-phenylthiosemicarbazone(74959-64-1)
• EPA Substance Registry System: 4-methoxybenzaldehyde N-phenylthiosemicarbazone(74959-64-1)

Safety Data

• Hazardous Substances Data: 74959-64-1(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 103-72-0 phenyl isothiocyanate 
• 302-01-2 hydrazine 
• 78255-58-0 2,4-bis(p-methoxyphenyl)-3-azabicyclo<3.3.1>nonan-9-one 
• 108-94-1 cyclohexanone 

Downstream Products

• 98052-60-9 2-(4-Methoxy-benzyliden-hydrazono)-4-oxo-3-phenyl-thiazolidin 
• 1093399-53-1 4-amino-1-(4-methoxybenzoyl)-2,7-dinitro-4'-phenylspiro(fluoren-9,3'-[1,2,4]triazolidine)-5'-thione 
• 129-79-3 2,4,7-trinitrofluorene-9-one 
• 84409-01-8 4-amino-2,7-dinitro-9-fluorenone 
• 74959-57-2 phenyl-(5-(4-methoxyphenyl)-3H-[1,3,4]thiadiazol-2-ylidene)amine 
• 1093399-47-3 1-[(4-methoxybenzoyl)-4-phenyl-3-thioxo-1,2,4-triazaspiro[4.5]deca-6,9-dien-8-ylidene]malononitrile 
• 1093399-41-7 4a-hydroxy-3-(4-methoxyphenyl)indeno[2,1-e][1,3,4]oxadiazin-9(4aH)-one 
• 1093399-45-1 3-cyano-4-oxo-N-phenylideno[1,2-c]pyrazole-1(4H)-carbothioamide 
• 110039-82-2 (Co(4-methoxybenzaldehyde)-4-phenyl-3-thiosemicarbazone)2(nitrate)2*H₂O 
• 110039-81-1 (Hg(4-methoxybenzaldehyde)-4-phenyl-3-thiosemicarbazone)2Cl₂) 
• 342631-72-5 [Pd(4-MeOC₆H₃C(H)=NN=C(S)NHPh)]4 

Relevant articles and documents

Structural revision of the Mcl-1 inhibitor MIM1: synthesis and biological studies on ovarian cancer cells with evaluation of designed analogues

In the area of cancer research, the development of new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic. The small molecule MIM1 has been reported earlier as one of the first selective inhibitors of the anti-apoptotic protein Mcl-1. In the present paper, we first revised the structure of this molecule based on extensive physicochemical analyses. Then we designed and synthesized a focused library of analogues for the corrected structure of MIM1. Next, these molecules were subjected to a panel ofin cellulobiological studies, allowing the identification of dual Bcl-xL/Mcl-1 inhibitors, as well as selective Mcl-1 inhibitors. These results have been complemented by fluorescence polarization assays with the Mcl-1 protein. Preliminary structure-activity relationships were discussed and extensive molecular modelling studies allowed us to propose a rationale for the biological activity of this series of new inhibitors, in particular for the selectivity of inhibition of Mcl-1versusBcl-xL

Carbothioamide as Highly Efficient Ligand for Copper-catalyzed Room Temperature Chan–Lam Cross-Coupling Reaction

The catalytic activity of three N,S-donor ligands, viz L1 [2-(4-methoxybenzylidene)-N-phenylhydrazinecarbothioamide], L2 [2,2′-(1,2-diphenylethane-1,2-diylidene)bis(hydrazinecarbothioamide)] and L3 [2-(4-methoxybenzylidene)hydrazinecarbothioamide] has been reported for N-arylation of imidazoles with arylboronic acids in ethanol at room temperature. The method was found to be applicable in N-arylation for a wide range of electronically diverse arylboronic acids with imidazoles having modest to excellent isolated yields. The in situ generated copper(II) complex of the ligand namely, 2-(4-methoxybenzylidene)-N-phenylhydrazinecarbothioamide (L1) was found to be highly efficient homogeneous catalyst for N-arylation reaction.

Efficient synthesis of novel 2,3-dihydro-1,3,5,4-thiadiazaphosphole derivatives

ABSTRACT: The condensation of various thiosemicarbazones with methyl thiophene-2-carboximidate afforded the corresponding intermediates 2a–2h. Subsequent cyclization of the latter compounds with hexamethylphosphorous triamide constitutes a new route to the synthesis of novel highly functionalized thiadiazaphosphole derivatives 4a–4h. This method offers significant advantages such as efficiency, high yields and mild reaction conditions.