74959-66-3

Upstream product

• 100-52-7 benzaldehyde 
• 101541-86-0 Triphenyl<(1,2,3-thiadiazol-4-yl)methyl>phosphonium-chlorid 
• 53941-18-7 trans-4-phenyl-3-buten-2-one tosylhydrazone 
• 1722-63-0 4-phenylbut-3-en-2-one semicarbazone 

Downstream Products

• 101541-96-2 5,8b-Dihydro-5,7-diphenyl-6H-1,2,3-thiadiazolo<5,4-c><1,2,4>triazolo<1,2-a>pyridazin-6,8(7H)-dion 
• 74959-80-1 4-styryl-2-thioxo-1,3-dithiole 

Relevant academic research and scientific papers

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst

Synthesis of novel 4-substituted 1,2,3-thiadiazoles via iodine-catalyzed cyclization reactions

Iodine-catalyzed the reaction of substituted methyl ketone N-tosylhydrazones with elemental sulfur has been developed. The cyclizations of the ester-substituted N-tosylhydrazone substrates proceeded smoothly under optimal reaction conditions, and the corr

Metal- and Oxidant-free Electrosynthesis of 1,2,3-Thiadiazoles from Element Sulfur and N-tosyl Hydrazones

A metal- and oxidant-free electrochemical method for synthesizing 1,2,3-thiadiazoles by inserting element sulfur into N-tosyl hydrazones is reported. This electrochemical transformation engages electrons as reagents to achieve redox processes, and avoid e

TBAI-Catalyzed Reaction between N-Tosylhydrazones and Sulfur: A Procedure toward 1,2,3-Thiadiazole

A TBAI-catalyzed reaction between N-tosyl hydrazone and sulfur was developed, leading to 1,2,3-thiadiazoles in moderate to good yields. It represents a facile and practical procedure to access thiadiazole under metal-free conditions. This procedure serves

4-Alkenyl-1,2,3-thiadiazoles

The title compounds 5 are prepared from the corresponding alkyl derivatives by bromination/dehydrobromination (route A) or by Wittig reaction (route B). 4-Phenyl-4H-1,2,4-triazole-3,5-dione yields the monoadducts 12 by maintenance of the thiadiazole ring.

Bromination and Dehydrobromination in the Side Chains of 1,2,3-Thiadiazoles

The bromination of 1,2,3-thiadiazoles with N-bromosuccinimide (NBS) is investigated.The monobromides 3 and 4 and the dibromides 5 and 6 can be isolated.Several methods have been used for the introduction of double bonds by the elimination of HBr.Besides the elimination products 9, 11, 12, and 14 the substitution products 10, 13, 15, 16, and 17 are obtained.A lot of regio- and stereoselectivities can be observed.

Selenium Heterocycles. XXX (1). Synthesis of 4-Substituted Vinyl 2-Thioxo-1,3-dithioles and 5-Substituted Vinyl 2-Thioxo-1,3-thiaselenoles

4-Substituted vinyl and 4-(4-phenyl-1,3-butadienyl)-1,2,3-thiadiazoles were prepared through the reaction of 4-aryl-3-buten-2-one semicarbazone and 6-phenyl-3,5-hexadien-2-one semicarbazone with thionyl chloride, respectively.Decomposition of these 1,2,3-thiadiazoles as well as the corresponding 1,2,3-selenadiazoles with base and subsequent addition of carbon disulfide afforded 4-substituted vinyl 2-thioxo-1,3-dithioles and 5-substituted vinyl 2-thioxo-1,3-thiaselenoles.