7496-52-8

Upstream product

• 630-10-4 selenourea 
• 98-86-2 acetophenone 
• 70-11-1 α-bromoacetophenone 
• 3425-46-5 potassium selenocyanate 
• 536-74-3 phenylacetylene 
• 13665-04-8 2,2-dibromoacetophenone 
• 537691-43-3 2-benzoylamino-4-phenyl-1,3-selenazole 

Downstream Products

• 537691-43-3 2-benzoylamino-4-phenyl-1,3-selenazole 
• 57739-39-6 7-oxo-3-phenyl-7H-selenazolo[3,2-a]pyrimidine-5-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Supramolecular synthesis of selenazoles using selenourea in water in the presence of β-cyclodextrin under atmospheric pressure

Selenazoles were synthesized from α-bromo ketones and selenourea in the presence of β-cyclodextrin in water at 50 °C under atmospheric pressure.

A convenient synthesis of 2-amino-1,3-selenazoles using ionic liquids and microwave irradiation

A simple and environmentally benign synthesis of 2-amino-1,3-selenazoles by microwave irradiation using 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4) ionic liquid (IL) is described. Acyl halides, phenacyl halides, and-bromo-keto est

Selenazole diphosphonic acid compound and preparation method thereof

The invention belongs to the technical field of medicines, and discloses a selenazole diphosphonic acid compound and a preparation method thereof, the structural characteristics of the compound are identified, the selenazole diphosphonic acid compound has

Design, synthesis, and biological evaluation of 4-aminopyrimidine or 4,6-diaminopyrimidine derivatives as beta amyloid cleaving enzyme-1 inhibitors

A series of novel aminopyrimidine and diaminopyrimidine derivatives were designed and optimized to improve their potency and permeability relative to lead compound 1 (IC50?=?37.4?μM), which was discovered in a previous virtual screening. The po

Green approach: An efficient synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles in aqueous medium under ultrasonic irradiation

An efficient and rapid procedure for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles has been described by the reaction of α-bromoketones with thiourea, phenylthiourea and selenourea at ambient temperature in aqueous medium under ultrasonic irradiation. Analytically pure products were formed within 10-60 s in excellent yields. The advantageous features of this non-conventional methodology over conventional methods are the operational simplicity, easy handling, yield-enhancing, time-reducing, mild reaction conditions and no by-product production.

Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature

Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one and thiourea/ phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 min in excellent yields.

A tandem one-pot aqueous phase synthesis of thiazoles/selenazoles

The first ever tandem one-pot synthetic protocol for the synthesis of thiazoles/selenazoles from alkynes via the formation of 2,2-dibromo-1- phenylethanone is reported. The reaction is catalyzed by β-cyclodextrin in aqueous medium and resulted in good yields.

Solid-state synthesis of 1,3-selenazoles employing CuPy2Cl 2 as a Lewis acid catalyst

1,3-Selenazoles were Synthesized from 3-bromo acetyl coumarin and selenourea in the presence of CuPy2Cl2 under solvent-free conditions at ambient temperature. The pure products were identified by spectral data. Copyright Taylor & Francis Group, LLC.

Synthesis of 1,3-selenazoles and bis(selenazoles) from primary selenocarboxylic amides and selenourea

The reaction of nitriles with P2Se5 in the presence of EtOH-H2O afforded primary selenocarboxylic amides. The cyclization of these compounds with α-halo ketones afforded a variety of functionalized 1,3-selenazoles. The use of P2Se5 also allowed the convenient synthesis of selenocarboxylic diamides which were transformed into bis(selenazol-2-yl)alkanes ('bis-selenazoles'). A practical method for the synthesis of selenourea was developed. This useful small building block was successfully applied to the synthesis of primary 2-amino-1,3- selenazoles.

Synthesis and Reactivity of 2-Acyl-1,3-selenazoles

2-Acyl-1,3-selenazoles were prepared in two steps from α- bromoketones and seleno amides. The base mediated fragmentation of these compounds afforded 2-unsubstituted 1,3-selenazoles. The reaction of 2-acyl-1,3-selenazoles with hydroxylamine hydrochloride