74975-29-4

Usage

Also known as

4-chloro-3-formyl benzoyl isonicotinic acid
Belongs to the class of organic compounds known as pyridine carboxylic acids
Used in the synthesis of various pharmaceutical drugs
Utilized in research and development in the fields of medicine and biochemistry
Important building block for the creation of new molecules and potential drug candidates
Shows potential in antimicrobial and antitumor activities
Valuable chemical in the pharmaceutical industry

Upstream product

• 4664-08-8 cinchomeronic anhydride 
• 108-90-7 chlorobenzene 
• 55-22-1 pyridine-4-carboxylic acid 
• 62-53-3 aniline 
• 3034-31-9 N-phenylisonicotinamide 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 857042-98-9 C₁₅H₁₂ClN₃O 

Relevant academic research and scientific papers

1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: Identification of BTA9881 as a preclinical candidate

Respiratory syncytial virus (RSV) is a major cause of respiratory tract infections in infants, young children and adults. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones with general structure 1 were previously identified as promising inhibitors of RSV targeting the fusion glycoprotein. In particular, the introduction of a nitrogen at the 8-position of the tricyclic core yielded lead compounds 2 and 3. Extensive exploration of the R2 group established that certain heterocyclic amides conferred potent RSV A&B activity and a good balance of physicochemical and pharmacokinetic properties. The antiviral activity was found to reside in a single enantiomer and compound 33a, (9bS)-9b-(4-chlorophenyl)-1-(pyridin-3-ylcarbonyl)-1,2,3,9b-tetrahydro-5H-imidazo[1′,2′:1,2]pyrrolo[3,4-c]pyridin-5-one (known as BTA9881), was identified as a candidate for preclinical development.

POLYCYCLIC AGENTS FOR THE TREATMENT OF RESPIRATORY SYNCYTIAL VIRUS INFECTIONS

Compounds of formula (I), and their use as in the treatment of infections involving viruses of the Pneumovirinae sub-family (RSV) are disclosed. In the formula ring (A) may be phenyl, pyridyl etc., (B-C) may be CH2-CH2etc., (R1) may be phenyl and substituted forms thereof, (R2) may be assorted substituents.

SYNTHESIS OF 2-AZAANTRAQUINONE AND ITS DERIVATIVES

The acylation of benzene, toluene, and chlorobenzene with cinchomeronic acid anhydride in the presence of AlCl3, has given in each case both possible isomers of the corresponding aroylpyridine carboxylic acid.It was found that the yields of reaction products and their isomeric compositions depend on the conditions of performing the reaction.The intramolecular cyclization on the isomeric keto acids in the presence of 2percent oleum has given 2-azaanthraquinone and chlorine derivatives of it.