749875-02-3

Basic information

• Product Name: 3-Chloro-2-(trifluoroMethyl)isonicotinic acid
• Synonyms: 3-Chloro-2-(trifluoroMethyl)isonicotinic acid
• CAS NO: 749875-02-3
• Molecular Formula: C₇H₃ClF₃NO₂
• Molecular Weight: 225.5524296
• EINECS: -0
• Mol File: 749875-02-3.mol

Chemical Properties

• Boiling Point: 353.3±42.0 °C(Predicted)
• Appearance: /
• Density: 1.603±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.39±0.28(Predicted)
• CAS DataBase Reference: 3-Chloro-2-(trifluoroMethyl)isonicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-2-(trifluoroMethyl)isonicotinic acid(749875-02-3)
• EPA Substance Registry System: 3-Chloro-2-(trifluoroMethyl)isonicotinic acid(749875-02-3)

Safety Data

• Hazardous Substances Data: 749875-02-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-2-(trifluoroMethyl)isonicotinic acid is used as a key intermediate in the synthesis of various active pharmaceutical ingredients. Its unique structure and properties make it a valuable component in the development of new drugs.
Used in Agrochemicals:
TFMI acid is utilized in the synthesis of agrochemicals, contributing to the development of effective and innovative products for agricultural applications.
Used in Organic Chemistry:
3-Chloro-2-(trifluoroMethyl)isonicotinic acid is used as a building block for the preparation of potential anti-tuberculosis agents, showcasing its potential in the synthesis of compounds with significant therapeutic applications.
Used in Research and Development:
TFMI acid is employed in research and development for its unique structural and chemical properties, which allow for the exploration of new applications and the advancement of organic chemistry.

Upstream product

• 124-38-9 carbon dioxide 
• 749875-32-9 3-chloro-2-(trifluoromethyl)pyridine 
• 749875-03-4 3-chloro-4-iodo-2-(trifluoromethyl)pyridine 
• 77332-89-9 2-iodo-3-pyridyl chloride 

Downstream Products

• 1034132-12-1 ethyl 4-hydroxy-1-methyl-2-oxo-6-phenyl-8-(trifluoromethyl)-1,2-dihydro-1,7-naphthyridine-3-carboxylate 
• 1034132-07-4 methyl 3-chloro-2-(trifluoromethyl)isonicotinate 

Relevant articles and documents

GLYCINE TRANSPORTER INHIBITOR

The present invention provides a compound represented by the following formula or a pharmaceutically acceptable salt of the compound or a hydrate of the compound or the salt, which is useful for the prevention or treatment of diseases such as schizophreni

Further metalations and functionalizations of chloro-, bromo- and iodo(trifluoromethyl)pyridines

In accordance with the concept of regioexhaustive functionalization, both 3-chloro-2-(trifluoromethyl)pyridine and 2-bromo-6-(trifluoromethyl)pyridine were converted each time into the three possible carboxylic acids (1, 4 and 5 and 6, 9 and 12, respectively). 2-Bromo-4-(trifluoromethyl)pyridine, 2-bromo-5-(trifluoromethyl)pyridine, 2-iodo-4-(trifluoromethyl)pyridine and 4-iodo-2-(trifluoromethyl)pyridine were selectively deprotonated and subsequently carboxylated at the respective 3-positions thus affording the acids 13-16. Finally, the N-pivaloyl-protected 2-amino-3-chloro-5-(trifluoromethyl) pyridine was deprotonated at the 4-position and the intermediate trapped with iodine and benzaldehyde to provide, after amide cleavage, the aminopyridines 17 and 18.