749875-07-8

Usage

Uses

Used in Pharmaceutical Industry:
2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID is used as a key intermediate in the synthesis of various pharmaceuticals for its potential biological activities. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID is utilized as a building block for the creation of novel agrochemicals, contributing to the advancement of crop protection and pest management strategies.
Used in Organic Synthesis:
2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID is employed as a versatile intermediate in organic synthesis, enabling the production of a wide range of chemical compounds for various applications, including the synthesis of complex organic molecules and the development of new materials.
Used in Medicinal Chemistry Research:
2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID is also used as a valuable research tool in medicinal chemistry, facilitating the exploration of new drug targets and the optimization of lead compounds for therapeutic applications. Its unique reactivity and structural features make it an attractive candidate for the design and synthesis of innovative pharmaceutical agents.

InChI:InChI=1/C7H3BrF3NO2/c8-5-3(6(13)14)1-2-4(12-5)7(9,10)11/h1-2H,(H,13,14)

Upstream product

• 144740-56-7 methyl 2-bromo-6-(trifluoromethyl)nicotinate 
• 144740-55-6 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyridine-3-carboxylic acid methyl ester 
• 124-38-9 carbon dioxide 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 

Relevant academic research and scientific papers

COMPOUNDS, COMPOSITIONS AND METHODS

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

A process for preparing 3 - substituted -2 - bromo -6 - trifluoromethyl pyridine

The invention discloses a method of preparing 3-substituted-2-bromo-6-trifluoromethyl pyridine. The method comprises the following steps: in the presence of nitrogen, reacting 2-bromo-6-trifluoromethyl pyridine used as a raw material with lithium diisopropylamide at a low temperature to generate 3-site lithium salt, and then adding trimethyl borate, ethyl formate and carbon dioxide respectively to generate 2-bromo-6-trifluoromethyl-3-pyridineboronic acid, 2-bromo-6-trifluoromethyl-3-pyridylaldehyde and 2-bromo-6-trifluoromethyl-3-picolinic acid; and reducing 2-bromo-6-trifluoromethyl-3-pyridylaldehyde by sodium borohydride to generate 2-bromo-6-trifluoromethyl-3-pyridinemethanol. The generated target compound is high in yield and good in purity, is an important medical intermediate, and has a wide application prospect. The method disclosed by the invention is simple and convenient to operate, easily available in raw materials, good in reaction selectivity, environment-friendly, easy for enlarged production, and capable of realizing commercialized products.

Further metalations and functionalizations of chloro-, bromo- and iodo(trifluoromethyl)pyridines

In accordance with the concept of regioexhaustive functionalization, both 3-chloro-2-(trifluoromethyl)pyridine and 2-bromo-6-(trifluoromethyl)pyridine were converted each time into the three possible carboxylic acids (1, 4 and 5 and 6, 9 and 12, respectively). 2-Bromo-4-(trifluoromethyl)pyridine, 2-bromo-5-(trifluoromethyl)pyridine, 2-iodo-4-(trifluoromethyl)pyridine and 4-iodo-2-(trifluoromethyl)pyridine were selectively deprotonated and subsequently carboxylated at the respective 3-positions thus affording the acids 13-16. Finally, the N-pivaloyl-protected 2-amino-3-chloro-5-(trifluoromethyl) pyridine was deprotonated at the 4-position and the intermediate trapped with iodine and benzaldehyde to provide, after amide cleavage, the aminopyridines 17 and 18.

Herbicidal pyridine sulfonamide

A pyridine sulfonylurea herbicide, composition thereof and a method for its use that results in the control of blackgrass in cereal crops and general control of all plant growth.