749875-07-8

Basic information

• Product Name: 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID
• Synonyms: 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID;2-bromo-6-trifluoromethyl-3-pyridinecarboxylic acid;2-Bromo-6-trifluoromethyl nicotinic acid;2-broMo-6-(trifluoroMethyl)pyridine-3-carboxylic acid;2-Bromo-6-(trifluoromethyl)pyridine-3-carboxylic acid, 2-Bromo-3-carboxy-6-(trifluoromethyl)pyridine
• CAS NO: 749875-07-8
• Molecular Formula: C7H3BrF3NO2
• Molecular Weight: 270.0034296
• Mol File: 749875-07-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130-132°
• Boiling Point: 290℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.863
• Vapor Pressure: 0.000995mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID(749875-07-8)
• EPA Substance Registry System: 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID(749875-07-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 749875-07-8(Hazardous Substances Data)

Usage

General Description

2-Bromo-6-trifluoromethyl-3-pyridinecarboxylic acid is a chemical compound with the molecular formula C7H3BrF3NO2. It is a derivative of pyridine and contains a carboxylic acid functional group. 2-BROMO-6-TRUFLUOROMETHYL-3-PYRIDINECARBOXYLIC ACID is commonly used as a building block in organic synthesis and medicinal chemistry. It has been utilized in the development of pharmaceuticals and agrochemicals due to its potential biological activities. Additionally, it can be used as an intermediate in the production of various other chemical compounds. The presence of bromine and fluorine atoms in the structure contributes to its unique properties and reactivity, making it valuable in both research and industrial applications.

InChI:InChI=1/C7H3BrF3NO2/c8-5-3(6(13)14)1-2-4(12-5)7(9,10)11/h1-2H,(H,13,14)

Upstream product

• 144740-56-7 methyl 2-bromo-6-(trifluoromethyl)nicotinate 
• 144740-55-6 1,2-dihydro-2-oxo-6-(trifluoromethyl)pyridine-3-carboxylic acid methyl ester 
• 124-38-9 carbon dioxide 
• 189278-27-1 2-bromo-6-(trifluoromethyl)pyridine 

Relevant articles and documents

COMPOUNDS, COMPOSITIONS AND METHODS

The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NLRP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.

Further metalations and functionalizations of chloro-, bromo- and iodo(trifluoromethyl)pyridines

In accordance with the concept of regioexhaustive functionalization, both 3-chloro-2-(trifluoromethyl)pyridine and 2-bromo-6-(trifluoromethyl)pyridine were converted each time into the three possible carboxylic acids (1, 4 and 5 and 6, 9 and 12, respectively). 2-Bromo-4-(trifluoromethyl)pyridine, 2-bromo-5-(trifluoromethyl)pyridine, 2-iodo-4-(trifluoromethyl)pyridine and 4-iodo-2-(trifluoromethyl)pyridine were selectively deprotonated and subsequently carboxylated at the respective 3-positions thus affording the acids 13-16. Finally, the N-pivaloyl-protected 2-amino-3-chloro-5-(trifluoromethyl) pyridine was deprotonated at the 4-position and the intermediate trapped with iodine and benzaldehyde to provide, after amide cleavage, the aminopyridines 17 and 18.