7500-78-9

Basic information

• Product Name: BenzaMide, 2-benzoyl-
• Synonyms: BenzaMide, 2-benzoyl-;2-benzoylBenzamide
• CAS NO: 7500-78-9
• Molecular Formula: C₁₄H₁₁NO₂
• Molecular Weight: 225.24264
• Mol File: 7500-78-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 54-55 °C
• Boiling Point: 437.5°C at 760 mmHg
• Flash Point: 218.4°C
• Appearance: /
• Density: 1.209g/cm³
• Vapor Pressure: 7.46E-08mmHg at 25°C
• Refractive Index: 1.614
• PKA: 15.58±0.50(Predicted)
• CAS DataBase Reference: BenzaMide, 2-benzoyl-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzaMide, 2-benzoyl-(7500-78-9)
• EPA Substance Registry System: BenzaMide, 2-benzoyl-(7500-78-9)

Safety Data

• Hazardous Substances Data: 7500-78-9(Hazardous Substances Data)

Usage

Uses

2-Benzoylbenzamide is used as a reactant for the synthesis of 2,?4-?benzodiazepin-?1-?ones which is a potent CNS agent.

InChI:InChI=1/C14H11NO2/c15-14(17)12-9-5-4-8-11(12)13(16)10-6-2-1-3-7-10/h1-9H,(H2,15,17)

Upstream product

• 22103-85-1 2-benzoylbenzoyl chloride 
• 606-28-0 methyl o-benzoylbenzoate 
• 18852-53-4 3-chloro-3-phenylphthalide 
• 7335-63-9 3-methoxy-3-phenyl-phthalide 
• 85-52-9 2-Benzoylbenzoic acid 
• 91-15-6 phthalonitrile 
• 136918-14-4 phthalimide 

Downstream Products

• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 578-95-0 10H-acridin-9-one 
• 54768-74-0 N-Hydroxymethyl-(2-benzoyl)benzamide 
• 110458-56-5 (2-benzyl-phenyl)-arsonic acid 
• 28059-64-5 2-benzylaniline 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 

Relevant articles and documents

Synthetic method of 2-chloro-4-phenyl quinazoline

The invention relates to a synthetic method of 2-chloro-4-phenyl quinazoline and belongs to the technical field of organic synthetic chemistry. The synthetic method comprises the following steps of: by taking o-benzoylbenzoic acid as a raw material, performing an acylating chlorination reaction to generate o-benzoyl benzoyl chloride; performing an amidation reaction to generate o-benzoyl benzamide; performing a Hofmann degradation reaction to generate 2-amino benzophenone; and performing an annulations reaction to generate 4-phenyl quinazoline-2(1H)-one and chlorinating the 4-phenyl quinazoline-2(1H)-one by phosphorus oxychloride to finally generate 2-chloro-4-phenyl quinazoline, wherein the total yield is 20.8%. Compared with other methods, the reagents used by the route are low in price and easily available, and the post-treatment is simple. In the reaction process, the reaction conditions and synthetic processes thereof are explored, so that a simple and feasible synthetic route is provided for synthesizing 2-chloro-4-phenyl quinazoline, thereby realizing amplified production.