122333-94-2Relevant articles and documents
Side chain methyl analogues of Δ8-THC
Huffman, John W.,Lainton, Julia A.H.,Banner, W. Kenneth,Duncan Jr., Sammy G.,Jordan, Robert D.,Yu, Shu,Dai, Dong,Martin, Billy R.,Wiley, Jenny L.,Compton, David R.
, p. 1557 - 1576 (2007/10/03)
The synthesis of both side chain epimers of 1'- (4), 2'- (5), 3'-methyl- (6) and 4'-methyl-Δ8-tetrahydrocannobinol (7) has been carried out. The synthetic approach entailed the acid catalyzed condensation of the appropriate substituted resorcinol with menthadienol to provide the Δ8-THC analogue. Both isomers of 1'- (4) and 2'-Δ8-THC (5) were more potent than Δ8-THC, both in vitro and in vivo. The 3'-methyl isomers (6) were approximately equal in potency to Δ8-THC, and 4'-methyl-Δ8-THC was less potent. There was relatively little difference in potency between the epimers of 4, 5, and 6.
An Improved Synthesis of 6,8-Dimethoxy-3-methylisocoumarin, a Fungal Metabolite Precursor
Kendall, J. Kirby,Fisher, Thomas H.,Schultz, Harry P.,Schultz, Tor P.
, p. 4218 - 4220 (2007/10/02)
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