750512-44-8 Usage
Uses
Used in Pharmaceutical Industry:
(Z)-Cinnarizine is used as an active pharmaceutical ingredient for the development of medications targeting various medical conditions. Its unique stereochemistry may confer specific therapeutic effects, making it a valuable compound for drug discovery and pharmaceutical formulations.
Used in Research and Development:
(Z)-Cinnarizine serves as a crucial compound in scientific research, particularly in the field of stereochemistry, drug synthesis, and pharmaceutical development. It is utilized to study the effects of stereoisomerism on the pharmacokinetics, pharmacodynamics, and overall efficacy of drugs.
Used in Quality Control and Impurity Profiling:
As a specified impurity in the European Pharmacopoeia (EP), (Z)-Cinnarizine is used for quality control purposes in the manufacturing and testing of Cinnarizine-containing products. It helps ensure the purity, safety, and consistency of pharmaceuticals by providing a reference for impurity levels and potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 750512-44-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,5,0,5,1 and 2 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 750512-44:
(8*7)+(7*5)+(6*0)+(5*5)+(4*1)+(3*2)+(2*4)+(1*4)=138
138 % 10 = 8
So 750512-44-8 is a valid CAS Registry Number.
750512-44-8Relevant academic research and scientific papers
Stereoselective synthesis of (z)-1-benzhydryl-4-cinnamylpiperazines via the wittig reaction
Shivprakash,Reddy, G. Chandrasekara
, p. 600 - 609 (2014/01/17)
A synthetic method of producing (E)- and (Z)-isomers of 1-benzhydryl-4-cinnamylpiperazines in a specific ratio from corresponding benzhydrylpiperazine is described. Of the three compounds synthesized (5a-c), the ratio of E/Z-isomers remained around 15:85. The key intermediates, 1-benzhydryl-4-(2,2-dimethoxyethyl)piperazine derivatives (3a-c), were prepared by nucleophilic substitution reaction of benzhydrylpiperazines (2a-c) with chloroacetaldehyde dimethylacetal in good yield (up to 88%). Hydrolysis of 3a-c gave the corresponding aldehydes 4a-c, which when subjected to the Wittig reaction followed by column purification to afford 1a-c (E-isomers) and 6a-c (Z-isomers) in pure form. The isolated compounds were characterized by NMR and mass spectral analysis. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications for the following free supplemental resource(s): Full experimental and spectral details.] Copyright
