75052-57-2

Upstream product

• 128061-93-8 (E)-2-{4-Oxo-5-[1-phenyl-meth-(Z)-ylidene]-4,5-dihydro-thiazol-2-yl}-3-phenyl-acrylonitrile 
• 109-77-3 malononitrile 
• 128798-19-6 (E)-2-(4-Hydroxy-thiazol-2-yl)-3-phenyl-acrylonitrile 
• 2700-22-3 Benzylidenemalononitrile 
• 100-52-7 benzaldehyde 
• 3364-82-7 2-(4-oxothiazolidine-2-ylidene)acetonitrile 
• 2365-48-2 Methyl thioglycolate 
• 5740-34-1 3-phenyl-2-sulfanylpropenoic acid 
• 623-51-8 ethyl 2-sulfanylacetate 
• 68-11-1 mercaptoacetic acid 
• 79421-53-7 2-Cyanomethyl-5-benzylidene-2-thiazolin-4-one 
• 74246-64-3 2-cyanomethyl-2-thiazolin-4-one 

Downstream Products

• 1350631-52-5 N-(5,7-dicyano-3,6-diphenyl-2N-ethoxyphthalimido-2H,6H-pyrazolo[3',4':4,5][1,3]thiazolo[3,2-a]pyridine-8-yl)benzamide 
• 1350631-47-8 N-(5,7-dicyano-3,6-diphenyl-2H,6H-pyrazolo[3',4':4,5][1,3]thiazolo[3,2-a]pyridine-8-yl)benzamide 
• 1350631-42-3 C₂₉H₁₈N₄O₂S 

Relevant academic research and scientific papers

Method and catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives

The invention discloses a method and a catalyst for preparing thiazolo [3, 2-alpha] pyridine derivatives, and belongs to the technical field of organic chemical industry. Magnetic material loaded alkaline ionic liquid is used as the catalyst, a molar ratio of aromatic aldehyde to active methylene compounds to methyl thioglycolate in preparation reaction is 2:(2-2.5):1, the molar weight, which is computed on the basis of alkaline ionic liquid on load, of the magnetic material loaded alkaline ionic liquid, which is the catalyst, is 8-12% of the molar weight of the methyl thioglycolate, and the reflux reaction time is 17-67 min. Compared with other preparation methods, the method and the catalyst have the advantages that the catalyst is low in loss during recycling and is high in recyclable times and product selectivity, integral preparation procedures are simple, convenient and economical, and accordingly industrial large-scale production can be facilitated.

One-pot synthesis of thiazolo[3,2-α]pyridine derivatives catalysed by ionic liquids

A green method for the synthesis of thiazolo[3,2-α]pyridine derivatives via the coupling of malononitrile, an aryl aldehyde and methyl thioglycolate in an ionic liquid has been developed. The advantages of this protocol are that it is non-toxic, no by-products are formed, short reaction times are required and high yields are obtained. Thiazolo [3,2-a]pyridines have important biological and medical applications.

Synthesis of ethoxyphthalimido derivatized thiazolodihydropyridines assembled with pyrazole and isoxazole systems from common intermediate chalcone and evaluation of their antibacterial activity

Condensation of aromatic aldehydes, malononitrile and thioglycolic acid gives 5-amino-3-oxo-7-substitutedphenyl-2-substitutedarylidene-2,3-dihydro-7H- [1,3]thiazolo[3,2-a] pyridine-6,8-dicarbonitrile 1a-e. This acts as key intermediate for two series of f

SYNTHESIS THROUGH REACTIONS OF NUCLEOPHILES WITH ACRYLONITRILES, PART 13: A DIRECT ONE-POT SYNTHESIS OF THIAZOLOPYRIDINES

Several new thiazolopyridines have been synthesized by a one-pot method through the ternary condensation of aldehydes with malononitrile and thioglycolic acid.Structure and reaction pathway are also reported. Key words: Heterocycles; thiazolopyridines; an

THE REACTION OF THIOGLYCOLIC ACID WITH α,β-UNSATURATED NITRILES: A NEW ROUTE FOR THE SYNTHESIS OF THIAZOLOPYRIDINES

The reaction of cinnamonitriles with thioglycolic acid in the presence of a basic catalyst affords thiazolopyridine derivatives.

Activated Nitriles in Heterocyclic Synthesis: The Reaction of nitriles with Mercapto Acides

Several new thiazolopyridine derivatives were obtained via the reaction of mercaptocinnamic acid and thioglycollic acid with some activated nitriles and treatment of the resulting 2-thiazolin-4-ones with cinnamonitrile derivatives. - Keywords: α-Me