750604-86-5

Basic information

• Product Name: 1-(5-(benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone
• Synonyms: 1-(5-(benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone
• CAS NO: 750604-86-5
• Molecular Weight: 387.233
• Mol File: 750604-86-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(5-(benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-(benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone(750604-86-5)
• EPA Substance Registry System: 1-(5-(benzo[d][1,3]dioxol-6-yl)-3-(4-bromophenyl)-4,5-dihydropyrazol-1-yl)ethanone(750604-86-5)

Safety Data

• Hazardous Substances Data: 750604-86-5(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 139-85-5 3,4-dihydroxybenzaldehyde 
• 36716-01-5 3-(3',4'-methylenedoxyphenyl)-1-(4'-bromophenyl)-2-propen-1-one 
• 64-19-7 acetic acid 
• 99-90-1 para-bromoacetophenone 

Relevant articles and documents

Synthesis, biological evaluation, 3D-QSAR studies of novel aryl-2H-pyrazole derivatives as telomerase inhibitors

A series of novel aryl-2H-pyrazole derivatives bearing 1,4-benzodioxan or 1,3-benzodioxole moiety were designed as potential telomerase inhibitors to enhance the ability of aryl-2H-pyrazole derivatives to inhibit telomerase, a target of anticancer. The telomerase inhibition tests showed that compound 16A displayed the most potent inhibitory activity with IC50 value of 0.9 μM for telomerase. The antiproliferative tests showed that compound 16A exhibited high activity against human gastric cancer cell SGC-7901 and human melanoma cell B16-F10 with IC50 values of 18.07 and 5.34 μM, respectively. Docking simulation showed that compound 16A could bind well with the telomerase active site and act as telomerase inhibitor. 3D-QSAR model was also built to provide more pharmacophore understanding that could be used to design new agents with more potent telomerase inhibitory activity.