75074-03-2Relevant academic research and scientific papers
Design, synthesis and systematic evaluation of all possible cyclic dinucleotides (CDNs) that activate human stimulator of interferon genes (STING) variants
Li, Lu-Yuan,Ma, De-Jun,Wang, Chuan-Lin,Wang, Da-Wei,Wang, Zheng-Hua,Wen, Xin,Xi, Zhen,Zhang, Hang,Zhang, Qiang-Zhe,Zhao, Can-Can
, (2020/04/10)
Cyclic dinucleotides (CDNs) are known to activate stimulator of interferon genes (STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence
Nucleotides, XVI. - Synthesis and Properties of Adenylyl-adenylyl-adenosines
Charubala, Ramamurthy,Uhlmann, Eugen,Pfleiderer, Wolfgang
, p. 2392 - 2406 (2007/10/02)
The completely protected adenylyl(2',5')adenylyl(2',5')adenosines 21 and 22 have been synthesized in preparative scale by the phosphotriester approach applying the o-chlorophenyl and p-nitrophenylethyl group, respectively, as phosphate protective groups.D
Synthesis and properties of adenylate trimers A2′p5′A2′p5′A, A2′p5′A3′p5′A and A3′p5′A2′p5′A
Charubala, Ramamurthy,Pfleiderer, Wolfgang
, p. 1933 - 1936 (2007/10/02)
Triadenylates with (2′-5′)(2′-5′) and mixed (2′-5′)(3′-5′) and (3′-5′)(2′-5′) linkages respectively were synthesized via the phosphotriester approach followed by deblocking of the fully protected intermediates. The isomeric trimers were characterized by NMR- and CD-spectra and show very similar hypochromicity effects.
