75077-45-1

Upstream product

• 97-00-7 1-chloro-2,4-dinitro-benzene 
• 2450-71-7 Propargylamine 

Downstream Products

• 122457-25-4 2-(N-propargylamino)-5-nitroaniline 
• 1245006-47-6 (S)-2-(3-((S)-1-carboxy-5-(4-((2,4-dinitrophenylamino)methyl)-1H-1,2,3-triazol-1-yl)pentyl)ureido)pentanedioic acid 
• 122457-31-2 2-amino-8-methyl-3-trideuteromethylimidazo[4,5-f]quinoxaline 
• 120885-31-6 3-methyl-6-nitroquinoxaline 
• 4236-41-3 3-methyl-6-aminoquinoxaline 

Relevant academic research and scientific papers

Synthesis of the Food Mutagens MeIQx and 4,8-DiMeIQx by Copper(I) Promoted Quinoxaline Formation

The regiocontrolled syntheses of the title compounds (1 and 2) is described.The key step is a new intramolecular alkyne amination and aromatization process (5 6; 8 9) effected by tetrakis(acetonitrile)copper(I) tetrafluoroborate.

COVALENT IMMUNE RECRUITER COMPOUNDS FOR IMMUNE CELL RECOGNITION AND ASSOCIATED USES

The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies. [in-line-formulae]ABD?(L1)n-ALD-(L2)m-R[/in-line-formulae]