75077-46-2

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 2450-71-7 Propargylamine 
• 100-01-6 4-nitro-aniline 
• 106-96-7 propargyl bromide 

Downstream Products

• 123685-48-3 N-[3,4-Dihydro-6-[[(4-nitrophenyl)-2-propynylamino]methyl]4-oxo-2-quinazolinyl]-2,2-dimethylpropanamide 
• 111493-23-3 3-(4-Nitro-phenyl)-5-prop-2-yn-(E)-ylidene-oxazolidin-2-one 
• 111493-14-2 5-[1-Iodo-meth-(E)-ylidene]-3-(4-nitro-phenyl)-oxazolidin-2-one 
• 1616405-30-1 N-methyl-4-nitro-N-((1-tosyl-1H-1,2,3-triazol-4-yl)methyl)aniline 
• 1616405-40-3 (E)-4-methyl-N-((1-methyl-5-nitro-1H-indol-3-yl)methylene)benzenesulfonamide 
• 109769-27-9 N-methyl-4-nitro-N-(prop-2-yn-1-yl)aniline 
• 1449498-93-4 N¹-methyl-N¹-(prop-2-yn-1-yl)benzene-1,4-diamine 
• 613-50-3 6-nitroquinoline 
• 123685-36-9 2-amino-6-[[(4-nitrophenyl)-2-propynylamino]methyl]-4(3H)-quinazolinone 
• 100-01-6 4-nitro-aniline 
• 111493-06-2 (4-Nitro-phenyl)-prop-2-ynyl-carbamic acid ethyl ester 

Relevant academic research and scientific papers

New Hydroxyquinoline-Based Derivatives as Potent Modulators of Amyloid-β Aggregations

Copper and zinc have been found to contribute to the burden of amyloid-β (Aβ) aggregations in neurodegenerative Alzheimer's disease (AD). Dysregulation of these metals leads to the generation of reactive oxygen species (ROS) and eventually results in oxid

Synthesis of substituted 3-indolylimines and indole-3-carboxaldehydes by rhodium(II)-catalyzed annulation

An efficient Cu/Rh-catalyzed method is proposed for the synthesis of 3-indolylimines from N-propargylanilines through Rh(II)-catalyzed denitrogenative annulation of N-sulfonyl-1,2,3-triazoles. Further combined with hydrolysis or reduction, a one-pot method is developed to enable the direct incorporation of an imine, aldehyde, or amine group into an indole system from an alkyne. A variety of substituted 3-indolylimines, indole-3-carboxaldehydes, and 3-Indolylmethanamines are synthesized in good yields.

Anticancer (hexacarbonyldicobalt)propargyl aryl ethers: Synthesis, antiproliferative activity, apoptosis induction, and effect on cellular oxidative stress

While an increasing number of (hexacarbonyldicobalt)alkynes have been found to possess antiproliferative activity against a number of cancer cell lines, the role of the organometallic moiety in this bioactivity is not well understood. To gain a better und

Palladium-catalyzed cleavage of O/N-propargyl protecting groups in aqueous media under a copper-free condition

(Figure presented) A copper-free palladium-mediated cleavage of O/N-propargyl bonds in aqueous media has been investigated, affording a mild and convenient method for the deprotection of phenols and anilines. The methodology could be utilized for the selective removal of propargyl groups from aryl ethers and amines without affecting a variety of unprotected functional groups present in the substrates. The mechanism and scope of the reaction is discussed.

Intramolecular aromatic substitution and amino-claisen rearrangement in substituted N-(2-propynyl)anilines on electron impact

N-(2-Propynyl)anilines undergo amino-Claisen rearrangement to a minor extent in the ion source, losing a molecule of HCN under electron impact conditions. However, metastable molecular ions with energies closer to threshold undergo Claisen rearrangement g

Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines

The synthesis and biological activity of two series of nonclassical thymidylate synthase (TS) inhibitors are described. The first is a series of 10-propargyl-5.8-dideazafolic acid derivatives (10a-j) and the second is a series of the analogous 2-desamino

Antiproliferative cyclic compounds

A compound of formula (I) capable of inhibiting thymidylate synthase, a method for making such and a therapeutic process utilizing the compound of formula (I).

Substituted quinazolinones as anticancer agents

Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.