75097-27-7Relevant academic research and scientific papers
Cobalt-catalyzed redox-neutral synthesis of isoquinolines: C–H activation assisted by an oxidizing N–S bond
Wang, Fen,Wang, Qiang,Bao, Ming,Li, Xingwei
, p. 1423 - 1430 (2016/09/07)
A redox-neutral avenue to access isoquinolines has been realized by a Co(III)-catalyzed C–H activation process. Starting from readily available N-sulfinyl imine substrates and alkynes, the reaction occurred via N–S cleavage with broad substrate scope and functional group compatibility in the presence of cost-effective cobalt catalysts.
Nickel-catalyzed cycloaddition of aromatic (O-benzyl)ketoximes with alkynes to produce isoquinoline and isoquinoline N-oxide derivatives
Yoshida, Yuji,Kurahashi, Takuya,Matsubara, Seijiro
supporting information; experimental part, p. 1140 - 1142 (2011/11/06)
A nickel-catalyzed cycloaddition of aromatic (O-benzyl)-ketoximes with alkynes to afford 3,4-disubstituted isoquinoline derivatives has been developed. The reaction involves oxidative addition of N-O bond of O-benzylketoxime to Ni(0) and subsequent intermolecular C-H bond activation via elimination of benzyl alcohol. It was also found that ketoximes participate in the nickel-catalyzed reaction with alkynes to furnish isoquinoline N-oxide derivatives.
Synthesis of isoquinolines via rhodium(III)-catalyzed dehydrative C-C and C-N coupling between oximines and alkynes
Zhang, Xingping,Chen, Dan,Zhao, Miao,Zhao, Jing,Jia, Aiqun,Li, Xingwei
supporting information; experimental part, p. 719 - 723 (2011/05/08)
Isoquinolines have been synthesized from the redox-neutral dehydrative C-N and C-C cross-coupling between oximines and alkynes using a catalytic amount of (pentamethylcyclopentadiene)rhodium dichloride dimer {[RhCp*Cl 2]2} and cesium
PREPARATION OF 1,4-DIPHENYL-3-SUBSTITUTED ISOQUINOLINES
Mataka, Shuntaro,Takahashi, Kazufumi,Tsuda, Yuhsuke,Tashiro, Masashi
, p. 789 - 792 (2007/10/02)
The reaction of o-dibenzoylbenzene (1) with benzylamine (2a), m-(2b) and p-xylylendiamine (2c), n-butylamine (2d), ethylglycinate (2f) and aminoacetonitrile (2g) in the presence of basic catalysts afforded the corresponding 3-substituted 1,4-diphenylisoquinolines (3a-d, f, g, and i), while the reaction of 1 with ethanolamine (2e) gave a trace amount of 3-hydroxymethylisoquinoline (3e) and 1,3-diphenylisobenzofuran (4) in 25percent yield.
