75105-03-2Relevant articles and documents
A Mild Synthesis of 2-Substituted Benzothiazoles via Nickel-Catalyzed Intramolecular Oxidative C-H Functionalization
Gao, Ming-Yuan,Li, Jing-Hang,Zhang, Shi-Bo,Chen, Li-Jun,Li, Yue-Sheng,Dong, Zhi-Bing
, p. 493 - 500 (2020/02/04)
A highly efficient synthetic method for the preparation of 2-aminobenzothiazoles starting from arylthioureas has been reported. By using a nickel catalyst, arylthioureas undergo intramolecular oxidative C-H bond functionalization, giving the desired 2-aminobenzothiazoles in good to excellent yields. This protocol features an inexpensive catalyst, low catalyst loading, mild reaction conditions, a short reaction time, and good to excellent yields, and it can be scaled up easily to a gram scale with almost no yields decreasing.
Solid Supported Nano Structured Cu-Catalyst for Solvent/Ligand Free C2 Amination of Azoles
Dutta, Pratip Kumar,Sen, Subhabrata,Saha, Debasree,Dhar, Basabbijayi
supporting information, p. 657 - 665 (2018/02/14)
Ligand- and solvent-free catalytic conditions that harness a nanostructured–CuI catalyst encapsulated in TiO2 has been reported for C2-amination of azoles (benzothiazole, benzoxazole and thiazole). The reaction is highly regioselective. The catalyst is robust, inexpensive and can be recycled up to four times. This strategy was further used for the synthesis of a small molecule with anti-HIV and anti-tumor properties.
