7511-70-8Relevant articles and documents
Discovery of Diphenoxy Derivatives with Flexible Linkers as Ligands for β-Amyloid Plaques
Jia, Jianhua,Zhang, Longfei,Song, Jia,Dai, Jiapei,Cui, Mengchao
, p. 4089 - 4100 (2020/12/13)
The highly rigid and planar scaffolds with π-conjugated systems have been widely considered to be indispensable for β-amyloid (Aβ) binding ligands. In this study, a library of diphenoxy compounds with different types of more flexible linkers as Aβ ligands were synthesized and evaluated. Most of them displayed good affinity (Ki1-42aggregates, and some ligands even showed values of Kiless than 10 nM. Structure-activity relationship analysis revealed that modification on the linkers or substituents tolerated great flexibility, which challenged the long-held belief that rigid and planar structures are exclusively favored for Aβ binding. Three ligands were labeled by iodine-125, and they exhibited good properties in vitro and in vivo, which further supported that this flexible scaffold was potential and promising for the development of Aβ imaging agents.
Synthesis and Characterization of a New Difunctional Ligand and Its Metal Complexes: An Experimental, Theoretical, Cyclic Voltammetric, and Antimicrobial Study
Baykara, Haci,Ilhan, Salih,Oztomsuk, Abdussamet,Seyitoglu, M. Salih,Levent, Abdulkadir,Okumus, Veysi,Dündar, Abdurrahman
, p. 1795 - 1807 (2015/08/06)
A new difunctional Schiff base ligand and its some metal complexes were synthesized. The compounds were characterized by elemental analysis, 1H-NMR, 13C-NMR, FT-IR, UV-VIS, magnetic susceptibility measurements, molar conductivity mea
