7511-88-8

Usage

Type of compound

dinitrile

Number of nitrile functional groups

two

Backbone structure

butane

Substituent groups

4-methylphenyl group, phenyl group

Usage

production of pharmaceuticals, agrochemicals, and other organic compounds

Potential applications

research and development

Safety precautions

handle with care and follow proper safety guidelines due to potentially hazardous nature

Upstream product

• 10077-34-6 2-phenyl-3-p-tolyl-acrylonitrile 
• 151-50-8 potassium cyanide 
• 7496-27-7 α-(p-tolyl)-β-phenylacrylonitrile 
• 773837-37-9 sodium cyanide 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 100-52-7 benzaldehyde 

Downstream Products

• 95280-72-1 2-phenyl-3-p-tolyl-succinic acid 
• 5468-18-8 2-phenyl-3-p-tolyl-succinic acid diamide 
• 1398057-65-2 3-phenyl-4-(p-tolyl)-1H-pyrrole 
• 1882-56-0 2-(4-methylphenyl)-2-phenylacetic acid 

Relevant academic research and scientific papers

Synthesis of non-symmetrical 3,4-diaryl-substituted pyrroles: Implementation for the preparation of lamellarin R

A straightforward method for synthesising symmetrical and non-symmetrical 3,4-diaryl-substituted pyrroles is proposed, consisting of (i) the condensation reaction between phenylacetonitriles and aldehydes to give acrylonitriles, (ii) the conjugate additio

A Paal-Knorr approach to 3,4-diaryl-substituted pyrroles: Facile synthesis of lamellarins O and Q

A very simple, yet efficient synthetic methodology, to obtain 3,4-diaryl-substituted pyrroles is described. The approach is based on the Knoevenagel condensation between arylacetonitriles and substituted aromatic aldehydes, followed by conjugate addition of cyanide to afford succinonitriles in excellent yields. The products thus obtained were subjected to DIBAL-H reduction, followed by cyclization under acidic conditions to produce the corresponding pyrroles in good overall yields. The utility of this protocol is exemplified by the synthesis of the marine alkaloids lamellarins O and Q.