75120-07-9Relevant articles and documents
Substrate-Based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase
Baguley, Tyler D.,Xu, Hai-Chao,Chatterjee, Manavi,Nairn, Angus C.,Lombroso, Paul J.,Ellman, Jonathan A.
, p. 7636 - 7650 (2013/11/06)
High levels of striatal-enriched protein tyrosine phosphatase (STEP) activity are observed in a number of neuropsychiatric disorders such as Alzheimer's disease. Overexpression of STEP results in the dephosphorylation and inactivation of many key neuronal