7515-47-1Relevant academic research and scientific papers
Expanding substrate scope of lipase-catalyzed transesterification by the utilization of liquid carbon dioxide
Hoang, Hai Nam,Matsuda, Tomoko
, p. 7229 - 7234 (2016/10/26)
Secondary alcohols having bulky substituents on both sides of the chiral center are often poor substrates for most lipases. Here we reported that substrate scopes of two of the most used lipases, Candida antarctica lipase B and Burkholderia cepacia lipase, were found to be expanded toward more bulky secondary alcohols such as 1-phenyl-1-dodecanol and 2-methyl-1-phenyl-1-propanol by simply using them in liquid carbon dioxide as a solvent. The effects of solvents, reaction pressure, and pre-treatment of the enzyme with liquid CO2on this acceleration phenomenon were also studied.
Products from solvolysis reactions that form (2-phenylcyclopropyl)carbinyl cations
Chandrasena, R. Esala P.,Aebisher, David,Newcomb, Martin
, p. 974 - 977 (2007/10/03)
Products from solvolytic reactions that form the (2-phenylcyclopropyl) carbinyl cation were determined. The majority of products (> 98%) derived from the 1-phenyl-3-butenyl cation, consistent with reports by Wiberg and co-workers. Small amounts of products derived from the 1-phenyl-1- cyclopropylmethyl cation also were found; these products were previously predicted to be formed from reactions of the title cation. Although the 1-phenyl-1-cyclopropylmethyl cation is considerably more stable than the 1-phenyl-3-butenyl cation, it is not kinetically accessible under a variety of solvolytic conditions. Copyright
Transesterification/Acylation of Secondary Alcohols Mediated by N-Heterocyclic Carbene Catalysts
Singh, Rohit,Kissling, Rebecca M.,Letellier, Marie-Anne,Nolan, Steven P.
, p. 209 - 212 (2007/10/03)
N-Heterocyclic carbenes (NHC) are efficient catalysts for transesterification/acylation reactions involving secondary alcohols. The catalytic transformations are carried out employing low catalyst loadings in convenient reaction times at room temperature.
CYCLOPROPYLCARBINYL COMPOUNDS FROM HOMOALLYLIC IODIDES
Previtera, Lucio,Monaco, Pietro,Mangoni, Lorenzo
, p. 1293 - 1294 (2007/10/02)
A simple synthesis of cyclopropylcarbinyl compounds based on the reaction of homoallylic iodides with silver salts in anhydrous medium is described.
