75152-19-1

Basic information

• Product Name: 5(4H)-Oxazolone, 2-(4-methoxyphenyl)-
• CAS NO: 75152-19-1
• Molecular Formula: C10H9NO3
• Molecular Weight: 191.186
• Mol File: 75152-19-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 5(4H)-Oxazolone, 2-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5(4H)-Oxazolone, 2-(4-methoxyphenyl)-(75152-19-1)
• EPA Substance Registry System: 5(4H)-Oxazolone, 2-(4-methoxyphenyl)-(75152-19-1)

Safety Data

• Hazardous Substances Data: 75152-19-1(Hazardous Substances Data)

Upstream product

• 13214-64-7 N-(4-methoxybenzoyl)glycine 
• 51220-57-6 ethyl 2-(4-methoxybenzamido)acetate 
• 100-07-2 4-methoxy-benzoyl chloride 
• 75152-16-8 (4-Methoxy-benzoylamino)-acetic acid 4-nitro-phenyl ester 

Relevant articles and documents

Synthesis, cytotoxicity, and docking study of novel 1-naphthyl-5-aryl-1H-1,2,4-triazole-3-carboxamides

A new series of 1-naphthyl-5-aryl-1H-1,2,4-triazole-3-carboxamide derivatives were synthesized and structurally proved by 1H and 13C NMR along with high-resolution mass spectrometry. The cytotoxic activity of the newly synthesized compounds was evaluated. Compounds showed a pronounced inhibitory effect against cellular localization of tubulin. Flow cytometric analysis showed that Hep-G2 cells treated indicated a predominated growth arrest at the G2/M-phase compared to that of S-phase. Molecular modeling study using MOE program indicated that most of the target compounds showed good binding with the colchicine-binding site of β-subunit of tubulin with the binding free energy (?G) values of about 42?kJ/mol. Graphical abstract: [Figure not available: see fulltext.].

Synthesis of di- and tri-substituted imidazole-4-carboxylates via PBu3-mediated [3+2] cycloaddition

Some new di- and trisubstituted imidazole-4-carboxylates were prepared from amidoacetic acids 3 in the present report. The key step to establish such imidazole- 4-carboxylates stemmed from the PBu3-mediated [3+2] cycloaddition between in situ-generated Δ2-oxazolinone 4 and ethyl cyanoformate6. Our results indicated that trisubstituted imidazoles 7-20 were afforded in better yields than those of disubstituted imidazoles 21-27. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications1 to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

A kinetic study of the base-catalyzed dimerization of 5(4H)-oxazolones

The effects of the substituent at position-2 and kind of the base on the rate of the base-catalyzed dimerization of 5(4H)-oxazolones have been investigated. The electrondonating and strong steric effect of the substituent at position-2 reduce markedly the proclivity of 5(4H)-oxazolones to dimerization. The following catalytic activity sequence of the bases has been found: DBU >> Et3N > (i-Pr)2EtN.