51220-57-6

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE is used as a chemical intermediate for the synthesis of potential pharmaceutical drugs, contributing to the development of new medications.
Used in Cosmetic Industry:
In the cosmetic industry, ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE is used as a chemical intermediate, playing a role in the formulation of various cosmetic products.
Used as a Fragrance Ingredient:
ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE is used as a fragrance ingredient to add specific scents to different products, enhancing their sensory appeal.
Used as a Flavoring Agent in Food Products:
ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE is utilized as a flavoring agent in the food industry, contributing to the taste and aroma profiles of various food items.
Used in Medicinal Applications:
ETHYL 2-[(4-METHOXYBENZOYL)AMINO]ACETATE is recognized for its potential medicinal properties, such as antioxidant and anti-inflammatory effects, which may be harnessed in the development of therapeutic agents.

InChI:InChI=1/C12H15NO4/c1-3-17-11(14)8-13-12(15)9-4-6-10(16-2)7-5-9/h4-7H,3,8H2,1-2H3,(H,13,15)

Upstream product

• 623-33-6 glycine ethyl ester hydrochloride 
• 100-07-2 4-methoxy-benzoyl chloride 
• 30364-57-9 4-methoxybenzoic acid 2,5-dioxo-1-pyrrolidinyl ester 
• 459-73-4 GlyOEt*HCl 
• 122081-23-6 4-Methoxy-benzoic acid 4,5-dimethyl-[1,2,3]triazol-1-yl ester 
• 100-09-4 4-methoxybenzoic acid 
• 7464-46-2 p-nitrophenyl p-methoxybenzoate 
• 123-11-5 4-methoxy-benzaldehyde 
• 1290636-90-6 C₁₄H₁₀ClNO₅ 
• 105-13-5 4-Methoxybenzyl alcohol 
• 2999-46-4 Ethyl isocyanoacetate 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 122081-19-0 4-Methoxy-benzoic acid [2-[(Z)-hydroxyimino]-1-methyl-prop-(Z)-ylidene]-hydrazide 
• 3290-99-1 4-methoxybenzoic acid hydrazide 

Downstream Products

• 475481-08-4 2-(4-methoxy-benzoylamino)-pent-4-enoic acid ethyl ester 
• 477867-59-7 5-ethoxy-2-(4-methoxyphenyl)-1,3-oxazole 
• 75152-19-1 2-(4-methoxy-phenyl)-4H-oxazol-5-one 

Relevant academic research and scientific papers

Imidazole-based drug molecule with bactericidal activity, and preparation method thereof

The invention discloses an imidazole-based drug molecule with bactericidal activity, and a preparation method thereof, and belongs to the technical field of synthesis of antibacterial drugs. According to the present invention, the imidazole-based drug mol

Microwave-Assisted Ruthenium-Catalysed ortho-C?H Functionalization of N-Benzoyl α-Amino Ester Derivatives

A microwave-assisted highly efficient intermolecular C?H functionalization sequence has been developed to access substituted isoquinolones using α-amino acid esters as a directing group. This methodology enables a wide range of N-benzoyl α-amino ester derivatives to react via a Ru-catalysed C?H bond activation sequence, to form isoquinolones with moderate to excellent yields. As an additional advantage, our strategy proved to be widely applicable and also enabled the reaction of alkenes to provide access to alkenylated benzamides. The methodology was also extended towards the synthesis of isoquinoline alkaloids derivatives viz. oxyavicine and a dipeptide. The developed protocol is simple and cheap, avoids tedious workup procedures and works efficiently under MW irradiation. (Figure presented.).

Alpha-amino acrylate microbicide and preparation method and application thereof

The invention provides an alpha-amino acrylate microbicide and a preparation method and application thereof. The alpha-amino acrylate microbicide has a specific chemical structure formula shown as a formula I, and the formula I is shown in the description. The alpha-amino acrylate microbicide has the advantages that by utilizing the design principle of pesticide molecules, a medical leading compound with anti-coronavirus activity is performed with structure modification of agricultural plant virus-resisting activity, a series of alpha-amino acrylate derivatives is designed and synthesized, and particularly, the alpha-amino acrylate derivative containing piperidine ring is synthesized; the known compound is used as a positive reference compound to systematically screen the biology activity; a plurality of high-efficiency anti-virus leading molecules are provided for the developing of new pesticides, and the positive meaning is realized for the reduction application of the pesticide and the protection of environment ecology.

Copper-Catalyzed Aerobic Oxidative [2 + 3] Cyclization/Aromatization Cascade Reaction: Atom-Economical Access to Tetrasubstituted 4,5-Biscarbonyl Imidazoles

An atom-economical method for accessing tetrasubstituted 4,5-biscarbonylimidazoles by reaction between glycine derivatives and 5-alkoxyoxazoles is reported. The method, which involves a copper-catalyzed aerobic oxidative [2 + 3] cyclization/aromatization

Oxidative amidation of benzyl alcohols with amino acid esters mediated by N-hydroxysuccinimide/phenyliodine diacetate

A simple protocol involving metal-free oxidative amidation of benzyl alcohols with amino acid esters has been presented. The amidation proceeds in a radical pathway unlike in conventional metal-mediated extrusion of dihydrogen. The method is advantageous in terms of metal-free conditions, nonexpensive commercial starting substrates. Also various substituents in the starting materials are tolerated and sterically hindered amino acid side chains could provide good yields of amide products.

Benzyl [11C]Hippurate as an Agent for Measuring the Activities of Organic Anion Transporter 3 in the Brain and Multidrug Resistance-Associated Protein 4 in the Heart of Mice

Multidrug resistance-associated protein 4 (MRP4) and organic anion transporter 3 (OAT3) mediate the efflux of organic anions from the brain and heart. In this study, we have developed a probe for estimating the activity of these transporters in these tiss

Catalytic Asymmetric Synthesis of anti-α,β-Diamino Acid Derivatives

A novel approach to chiral anti-α,β-diamino acid derivatives through tandem orthogonal organocatalysis has been developed. Chiral phosphoric acid catalysts control the chemo-, regio-, and stereoselective addition of hydroxylamines to alkylideneoxazolones, while a phosphine catalyst promotes the isomerization of Z- alkylideneoxazolones to the more reactive E- alkylideneoxazolones. (Chemical Equation Presented).

Highly efficient and recyclable copper based ionic liquid catalysts for amide synthesis

A series of Cu based ionic liquids was synthesized by the reaction of 1-butyl-3-methylimidazolium salts and copper(ii) salts. These ionic liquids were investigated as catalysts in the synthesis of amides (primary, secondary and tertiary amides). For easy separation and recycling, the Cu based ionic liquids were decorated on nanocrystalline silicalite. The materials were characterized using powder X-ray diffraction, nitrogen adsorption, scanning and transmission electron microscopy, thermogravimetric analysis, and nuclear magnetic resonance, Fourier transform infrared and UV-visible spectroscopy. The Cu based ionic liquids decorated on nanocrystalline silicalite were found to be efficient and recyclable catalysts for the amide synthesis. The catalysts were found to be stable and show negligible loss of the activity even after five cycles.

The α-effect in hydrazinolysis of 4-chloro-2-nitrophenyl x-substituted-benzoates: Effect of substituent x on reaction mechanism and the α-effect

Second-order rate constants (kN) have been measured spectrophotometrically for the reaction of 4-chloro-2- nitrophenyl X-substituted-benzoates (6a-6h) with a series of primary amines including hydrazine in 80 mol % H2O/20 mol % DMSO at 25.0°C. The Bronsted-type plot for the reaction of 4-chloro-2-nitrophenyl benzoate (6d) is linear with βnuc = 0.74 when hydrazine is excluded from the correlation. Such a linear Bronsted-type plot is typical for reactions reported previously to proceed through a stepwise mechanism in which expulsion of the leaving group occurs in the rate-determining step (RDS). The Hammett plots for the reactions of 6a-6h with hydrazine and glycylglycine are nonlinear. In contrast, the Yukawa-Tsuno plots exhibit excellent linear correlations with ?X = 1.29-1.45 and r = 0.53-0.56, indicating that the nonlinear Hammett plots are not due to a change in RDS but are caused by resonance stabilization of the substrates possessing an electron-donating group (EDG). Hydrazine is ca. 47-93 times more reactive than similarly basic glycylglycine toward 6a-6h (e.g., the α-effect). The α-effect increases as the substituent X in the benzoyl moiety becomes a stronger electronwithdrawing group (EWG), indicating that destabilization of the ground state (GS) of hydrazine through the repulsion between the nonbonding electron pairs on the two N atoms is not solely responsible for the substituent-dependent α-effect. Stabilization of transition state (TS) through five-membered cyclic TSs, which would increase the electrophilicity of the reaction center or the nucleofugality of the leaving group, contributes to the α-effect observed in this study.

Three-component metal-free arylation of isocyanides

Mumm's the word: The title reaction can be performed by the addition of isocyanides to benzenediazonium salts in the presence of sodium or potassium carboxylates. The reaction involves nitrilium intermediates which may be trapped by water or carboxylic ac