75155-98-5

Upstream product

• 69309-71-3 3,3-diethoxyprop-1-ynylmagnesium bromide 
• 10160-87-9 Propiolaldehyde diethyl acetal 
• 16838-89-4 2,3,5-tri-O-benzyl-D-ribofuranose 
• 75155-97-4 (2R,3R,4S)-1,3,4-Tris-benzyloxy-8,8-diethoxy-oct-6-yne-2,5-diol 
• 50619-36-8 2,3,5-tri-Obenzyl-α,β-D-ribofuranosylchloride 

Downstream Products

• 59967-95-2 3(5)-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole 
• 75156-00-2 1-(2,4-dinitrophenyl)-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazole 
• 71052-62-5 (2S,3R,4S,5R)-2-[1-(2,4-Dinitro-phenyl)-1H-pyrazol-3-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol 
• 75155-99-6 1-(2,4-dinitrophenyl)-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrazole 
• 75173-95-4 1-(2,4-dinitrophenyl)-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)-4-nitropyrazole 

Relevant academic research and scientific papers

Identification and Characterization of Enzymes Catalyzing Pyrazolopyrimidine Formation in the Biosynthesis of Formycin A

Genome scanning of Streptomyces kaniharaensis, the producer of formycin A, reveals two sets of purA, purB, purC, and purH genes. The Pur enzymes catalyze pyrimidine assembly of purine nucleobases. To test whether enzymes encoded by the second set of pur genes catalyze analogous transformations in formycin biosynthesis, formycin B 5′-phosphate was synthesized and shown to be converted by ForA and ForB to formycin A 5′-phosphate. These results support that For enzymes are responsible for formycin formation.

C-Nucleoside Studies. Part 10. A New Synthesis of 3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)pyrazole and its Conversion into 4-Nitro-3(5)-β-D-ribofuranosylpyrazole

1,1-Diethoxy-3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)prop-2-yne (12) has been synthesised from 2,3,5-tri-O-benzyl-D-ribofuranose in 52percent yield.Acidic hydrolysis followed by reaction with hydrazine affords 3-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyraz

A New Synthesis of Formycin via Nitropyrazole Derivatives

3-(2,3,5-Tri-O-benzyl-β-D-ribofuranosyl)pyrazole (4) has been converted into formycin (15) by a sequence involving, as the key step, cine substitution, by cyanide ion, of the 1-nitro group in the 1,4-dinitro-pyrazole (10).

C-Nucleoside Studies. Part 9. Synthesis of 3(5)-α-D-Ribofuranosylpyrazole and Related Compounds

3-(1,2:4,5-Di-O-isopropylidene-D-allo-1,2,3,4,5-pentahydroxypentyl)-1-(2,4-dinitrophenyl)pyrazole (8) was prepared in four steps (40percent overall yield) from 2,3:5,6-di-O-isopropylidene-D-allose (4).Treatment of (8) with acetone and concentrated sulphur