7517-02-4Relevant academic research and scientific papers
A two-directional approach to a (-)-dictyostatin C11-C23 segment: Development of a highly diastereoselective, kinetically-controlled Meerwein-Ponndorf-Verley reduction
Dilger, Andrew K.,Gopalsamuthiram, Vijay,Burke, Steven D.
, p. 16273 - 16277 (2008/09/20)
A three-step synthesis of a precursor to the C11-C23 segment of (-)-dictyostatin is described. The sequence features a sonication-assisted, enantioselective double hetero Diels-Alder (HDA) reaction catalyzed by Jacobsen's Cr(III) Schiff base catalyst, followed by a novel, highly diastereoselective Meerwein-Ponndorf-Verley (MPV) reduction of the hydropyranone subunits under kinetic control to yield the bis-(axial alcohol) 4. Generalized studies of both the HDA and MPV methodologies are also described.
Aluminium-Carbon Bond Reactivity in Geminal Organodialuminium Compounds
Pasynkiewicz, S.,Dluzniewski, T.,Sonnek, Georg
, p. 1 - 6 (2007/10/02)
The reactions of 1,1-bis(diisobutylaluminium)hexane (1) with diethylamine, N-methylaniline, methanol and m-cresol have been studied.During partial protolysis both the aluminium-i-butyl bond and the aluminium-carbon bond in the aluminium-carbon-aluminium bridge undergo cleavage.The route of protolysis mainly depends on the protolytic agent used.The reaction of (1) with acetone has also been studied.Acetone was reduced to i-butanol with a 95percent yield.The ratio of the i-butyl to hexylidene groups from β-hydride elimination is 2:1.
