75172-64-4Relevant academic research and scientific papers
A chemoselective oxidation of monosubstituted ethylene glycol: Facile synthesis of optically active α-hydroxy acids
Chinthapally, Kiran,Baskaran, Sundarababu
supporting information, p. 4305 - 4309 (2014/06/23)
A mild and efficient method for the synthesis of optically active α-hydroxy acids through chemoselective oxidation of monosubstituted ethylene glycols using the TEMPO-NaOCl reagent system is described. It is evident from our studies that the solvent, pH and reaction temperature are very crucial for the success of this oxidation. The versatility of this method has been demonstrated with a variety of aliphatic, aromatic and carbohydrate substrates bearing various functional groups. the Partner Organisations 2014.
Enzymatic resolution of substituted mandelic acids
Campbell, Robert F.,Fitzpatrick, Kevin,Inghardt, Tord,Karlsson, Olle,Nilsson, Kristina,Reilly, John E.,Yet, Larry
, p. 5477 - 5481 (2007/10/03)
A series of substituted mandelic acids were prepared and subjected to enzymatic resolution utilizing Lipase PS 'Amano'.
A Convenient Route to (R)-α-Hydroxy Carboxylic Acids and (2R)-1-Amino-2-alkanols from (R)-Cyanohydrins
Ziegler, Thomas,Hoersch, Brigitte,Effenberger, Franz
, p. 575 - 578 (2007/10/02)
(R)-Cyanohydrins, prepared in good to excellent yields with high optical purity by enzyme-catalyzed addition of hydrogen cyanide to aldehydes in organic solvents, are hydrolyzed with concentrated hydrochloric acid at ambient temperature, usually in very high yield, without any trace of racemization to give (R)-α-hydroxy carboxylic acids.Likewise, no racemization is observed by direct reduction of the (R)-cyanohydrins with lithium aluminium hydride to give (2R)-1-amino-2-alkanols.
