75178-04-0Relevant articles and documents
HETEROARYLMETHYLENE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS
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Paragraph 0187, (2020/08/22)
Disclosed herein are certain acetamido derivatives that are DNA Polymerase Theta (Polθ) inhibitors of Formula (I). Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.
An efficient synthesis of N-substituted 3-nitrothiophen-2-amines
Kumar, Sundaravel Vivek,Muthusubramanian, Shanmugam,Menéndez, J. Carlos,Perumal, Subbu
supporting information, p. 1707 - 1712 (2016/04/10)
A novel protocol for the synthesis of 3-nitro-N-aryl/alkylthiophen-2-amines in good yields from the reaction of α-nitroketene N,S-aryl/alkylaminoacetals and 1,4-dithiane-2,5-diol in the presence of K2CO3 in refluxing ethanol is descr
Microwave-Assisted synthesis of nitroketene N, S-arylaminoacetals
Sangi, Diego P.,Corre?a, Arlene G.
experimental part, p. 795 - 799 (2010/09/05)
In this paper we report the use of microwaves as heat source to promote the synthesis of a series of nitroketene N, S-acetals with good to excellent isolated yields. These compounds are very useful intermediates for synthesizing nitrogen-containing hetero
