13623-94-4Relevant academic research and scientific papers
Nitroketene dithioacetal chemistry. Part 2: Synthesis of novel 4-(alkylsulfanyl)-2-[1-nitromethylidene]-1,3-dithioles from the dipotassium salt of 2-nitro-1,1-ethylenedithiol
Rao, H. Surya Prakash,Sakthikumar,Vanitha,Kumar, S. Siva
, p. 4701 - 4704 (2003)
The reaction of the dipotassium salt of 2-nitro-1,1-ethylenedithiol with long chain alkyl halides in acetonitrile medium furnished the novel heterocyclic, 4-(alkylsulfanyl)-2-[1-nitromethylidene]-1,3-dithioles.
Critical Influence of 5-Hydroxymethylfurfural Aging and Decomposition on the Utility of Biomass Conversion in Organic Synthesis
Galkin, Konstantin I.,Krivodaeva, Elena A.,Romashov, Leonid V.,Zalesskiy, Sergey S.,Kachala, Vadim V.,Burykina, Julia V.,Ananikov, Valentine P.
supporting information, p. 8338 - 8342 (2016/07/19)
Spectral studies revealed the presence of a specific arrangement of 5-hydroxymethylfurfural (5-HMF) molecules in solution as a result of a hydrogen–bonding network, and this arrangement readily facilitates the aging of 5-HMF. Deterioration of the quality of this platform chemical limits its practical applications, especially in synthesis/pharma areas. The model drug Ranitidine (Zantac) was synthesized with only 15 % yield starting from 5-HMF which was isolated and stored as an oil after a biomass conversion process. In contrast, a much higher yield of 65 % was obtained by using 5-HMF isolated in crystalline state from an optimized biomass conversion process. The molecular mechanisms responsible for 5-HMF decomposition in solution were established by NMR and ESI-MS studies. A highly selective synthesis of a 5-HMF derivative from glucose was achieved using a protecting group at O(6) position.
Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors
Dunkern, Torsten,Chavan, Sunil,Bankar, Digambar,Patil, Anuja,Kulkarni, Pritee,Kharkar, Prashant S.,Prabhu, Arati,Goebel, Heike,Rolser, Edith,Burckhard-Boer, Waltraud,Arumugam, Premkumar,Makhija, Mahindra T.
, p. 408 - 419 (2014/06/09)
This study is based on our attempts to further explore the structure-activity relationship (SAR) of VX-148 (3) in an attempt to identify inosine 5′-mono-phosphate dehydrogenase (IMPDH) inhibitors superior to mycophenolic acid. A five-point pharmacophore developed using structurally diverse, known IMPDH inhibitors guided further design of novel analogs of 3. Several conventional as well as novel medicinal chemistry strategies were tried. The combined structure- and ligand-based approaches culminated in a few analogs with either retained or slightly higher potency. The compounds which retained the potency were also checked for their ability to inhibit human peripheral blood mononuclear cells proliferation. This study illuminates the stringent structural requirements and strict SAR for IMPDH II inhibition.
HETEROCYCLIC SULFONAMIDE DERIVATIVES USEFUL AS MEK INHIBITORS
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Page/Page column 45, (2011/06/11)
The present invention relates to compounds of Formula (IA) Where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation.
Heterocyclic Sulfonamide Derivatives
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Page/Page column 16, (2011/08/08)
The present invention relates to compounds of Formula I where R1a, R1b, X, R2a, R2b, W, R3, R4, and R5 are as defined herein as well as pharmaceutically acceptable salts thereof. The compounds have been shown to act as MEK inhibitors which may be useful in the treatment of hyperproliferative diseases, like cancer and inflammation.
PREPARATION METHOD AND USE OF COMPOUNDS HAVING HIGH INSECTICIDAL ACTIVITIES
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Page/Page column 4, (2009/05/28)
The present invention discloses a kind of nitromethylene derivatives as well as their preparation method and their uses. The insecticidal activity tests show that the nitromethylene derivatives of the present invention not only show high insecticidal activities against insects with piercing-sucking type or scratching type mouthparts, such as aphid, leafhopper, plant hopper, thrips and white fly and their resistant strains, but also show high insecticidal activities against Lissorhoptrus oryzophilus, carmine spider mite, and they can also be used to prevent sanitary pest, and white ant.
PREPARATION METHOD AND USE OF COMPOUNDS HAVING HIGH BIOCIDAL ACTIVITIES
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Page/Page column 7, (2009/01/20)
The present invention discloses a kind of nitromethylene derivatives as well as their preparation method and their uses. The insecticidal activity tests show that the nitromethylene derivatives of the present invention not only show high insecticidal activities against insects with piercing-sucking type or scratching type mouthparts, such as aphid, leafhoppei, plant hopper, thrips and white fly and their resistant strains, but also show high insecticidal activities against Lissorhoptrus oryzophilus, carmine spider mite, and they can also be used to prevent sanitary pest, and white ant.
NITROMETHYLENE DERIVATIVES AND THEIR USE
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Page/Page column 5, (2008/06/13)
The present invention discloses nitromethylene derivatives and the uses thereof. These derivatives are obtained by adding ring structure onto the known nitromethylene compounds, by which both their stability for light and their liposolubility are increased. Furthermore, by using the substituents linked to ether bond, the steric orientation of the nitro group and the liposolubility of the compounds are controlled. The insecticidal activity tests show that the compounds and their derivatives of the invention display high efficiency on killing various destructive insects with piercing-sucking type or scratching type mouthparts, such as aphid, leafhopper, plant hpooer, thrips and white fly.
Synthesis and bioactivities of novel neonicotinoids dioxolane compounds
Tian, Zhongzhen,Li, Zhong,Huang, Qingchun,Xu, Xiaoyong,Yu, Tao,Wu, Yingli,Qian, Xuhong
, p. 626 - 628 (2007/10/03)
As candidates for the screening of neonicotinoid insecticides, nine novel compounds were designed and synthesised via Mannich reaction of (1,3-dioxolane-4-yl)methyl-2-(nitromethylene) imidazoline with corresponding primary amines and formaldehyde. Preliminary bioassays indicated that most of these compounds had moderate insecticidal activities against pea aphids.
Nitroketene acetal chemistry. 3. Facile synthesis of nitroacetic acid triarylmethyl ortho esters from 1,1-Di(methylsulfanyl)-2-nitroethylene
Rao, H. Surya Prakash,Sivakumar
, p. 4524 - 4527 (2007/10/03)
The reaction of 1,-di(methylsulfanyl)-2-nitroethylene, benzyl alcohols, and sodium hydride furnishes crystalline triarylmethyl ortho esters of nitroacetic acid.
