75195-67-4

Upstream product

• 4333-76-0 1-(4-bromophenyl)-1-phenylethene 
• 1070671-69-0 2-(4-bromophenyl)-2-phenyloxirane 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 

Downstream Products

• 5359-48-8 methyl 2-(4-bromophenyl)-2-phenylacetate 
• 1428526-75-3 diethyl 4-[(methoxycarbonyl)(phenyl)methyl]phenylphosphonate 
• 1428526-76-4 2-(4-(diethoxyphosphoryl)phenyl)-2-phenylacetic acid 
• 1428526-77-5 diethyl 4-(2-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-ylamino)-2-oxo-1-phenylethyl)phenylphosphonate 
• 21771-89-1 α-(4-bromophenyl)phenylacetic acid 

Relevant academic research and scientific papers

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins

Considering that stoichiometric borane and oxidant are required in the classical alkene anti-Markovnikov hydration process, it remains appealing to achieve the transformation in a catalytic protocol. Herein, a visible-light-mediated anti-Markovnikov addition of water to alkenes by using an organic photoredox catalyst in conjunction with a redox-active hydrogen atom donor was developed, which avoided the need for a transition-metal catalyst, stoichiometric borane, as well as oxidant. Both terminal and internal olefins are readily accommodated in this transformation to obtain corresponding primary and secondary alcohols in good yields with single regioselectivity. This procedure can be scaled up to gram scale with a 230 turnover number based on photocatalyst.

SUBSTITUTED PYRIMIDINES

Disclosed are substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.