752181-59-2

Usage

Uses

Used in Pharmaceutical Applications:
Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1S-trans)(9CI) is used as an intermediate in the synthesis of new drugs and pharmaceuticals. Its unique cyclic structure and functional groups make it a valuable building block for the development of innovative therapeutic agents.
Used in Peptide Synthesis:
In the field of peptide chemistry, Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1S-trans)(9CI) is used as a component in the synthesis of various peptides and peptide-based compounds. Its incorporation into peptide sequences can potentially enhance their stability, bioactivity, and other properties.
Used in Organic Synthesis:
Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1S-trans)(9CI) is also utilized in organic synthesis for the preparation of other organic compounds. Its versatile structure allows for various chemical reactions, enabling the synthesis of a wide range of molecules with different functional groups and properties.
Used in Laboratory Research:
In academic and industrial research settings, Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1S-trans)(9CI) is employed as a reagent and starting material for various chemical reactions and experiments. Its unique properties make it an interesting subject for studying the synthesis, properties, and potential applications of cyclic amino acid derivatives.
Overall, Cyclopentanecarboxylic acid, 2-amino-, ethyl ester, (1S-trans)(9CI) is a versatile and important chemical compound with a wide range of potential applications in the fields of chemistry, pharmaceuticals, and materials science. Its unique structure and properties make it a valuable asset for researchers and industry professionals alike.

Upstream product

• 22031-52-3 2-aza-3-oxobicyclo<3.2.0>heptane 
• 64-17-5 ethanol 
• 1033755-97-3 2-benzylamino-cyclopentanecarboxylic acid ethyl ester 
• 7149-18-0 ethyl 2-amino-1-cyclopentene-1-carboxylate 
• 611-10-9 2-ethoxycarbonyl-1-cyclopentanone 
• 142-29-0 cyclopentene 
• 22031-52-3 cis-2-aza-3-oxobicyclo<3.2.0>heptane 
• 151914-34-0 2,2,2-trifluoroethyl 1-chloroacetate 
• 38052-23-2 ethyl cis-2-amino-1-cyclopentane-carboxylate 
• 1609100-30-2 ethyl cis-2-aminocyclopentane-1-carboxylate 
• 1346004-19-0 (S,E)-ethyl 6-((1-(4-methoxyphenyl)ethyl)imino)hexanoate 
• 1346004-53-2 (1R,5S)-6-((S)-1-(4-methoxyphenyl)ethyl)-6-azabicyclo[3.2.0]heptan-7-one 
• 39155-94-7 (1R,5S)-6-azabicyclo[3.2.0]heptan-7-one 
• 5299-60-5 6-hydroxy-hexanoic acid ethyl ester 

Relevant academic research and scientific papers

SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF

Compounds of formula (I), processes for their production and their use as pharmaceuticals.

Diastereoselective Photoredox-Catalyzed [3 + 2] Cycloadditions of N-Sulfonyl Cyclopropylamines with Electron-Deficient Olefins

A highly diastereoselective, visible-light-induced [3 + 2] cycloaddition between N-sulfonyl cyclopropylamines and electron-deficient olefins is reported. The reactions proceed via the oxidation of a sulfonamide aza-anion by an organic photocatalyst to generate a nitrogen-centered radical. Strain-induced ring opening and intermolecular addition to the olefin generate an intermediate carbon-centered radical that is reduced to an anion prior to 5-exo cyclization. This enables a highly diastereoselective construction of trans-cyclopentanes possessing synthetically useful functional groups.

Dirhodium(II)-catalyzed [3 + 2] cycloaddition of N-arylaminocyclopropane with alkyne derivatives

Dirhodium(II) complex-catalyzed [3 + 2] reactions between N-arylaminocyclopropanes and alkyne derivatives are described. The cycloaddition products proved to be versatile synthetic intermediates. trans-Cyclic β-amino acids and derivatives thereof can be c

Dirhodium(II)-Catalyzed (3 + 2) Cycloaddition of the N-Arylaminocyclopropane with Alkene Derivatives

Several (3 + 2) cycloaddition reactions catalyzed by dirhodium(II) complexes between N-arylaminocyclopropane and alkenes derivative have been developed. Preliminary mechanism studies suggest that dirhodium(II) complexes may decrease the bond-dissociation

Synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols or 3-amino alcohols using iodobenzene dichloride and sodium azide

A general and efficient method for the synthesis of oxazolidin-2-ones and imidazolidin-2-ones directly from 1,3-diols and 3-amino alcohols has been developed using the same reagent combination of iodobenzene dichloride (PhICl2) and sodium azide (NaN3).

Expanding dynamic kinetic protocols: Transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives

Several α-alkylated β-amino esters have been obtained via DKR processes employing a kit of transaminases and isopropylamine as an amino donor in aqueous medium under mild conditions. Thus, while acyclic α-alkyl-β-keto esters afforded excellent conversions and enantioselectivities, although usually low diastereoselectivities, using more constrained cyclic β-keto esters high to excellent inductions were obtained.

AMINO QUINOLINE DERIVATIVES INHIBITORS OF HCV

A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein the substituents are defined herein, and methods of treating HCV infection in a patient are disclosed.

Intramolecular ester enolate-imine cyclization reactions for the asymmetric synthesis of polycyclic β-lactams and cyclic β-amino acid derivatives

Enolates of chiral N-(α-methyl-p-methoxybenzyl)-ω-imino-esters undergo intramolecular cyclization reactions to afford (syn)-aza-anions of β-amino esters in high dr that cyclize to afford N-(α-methyl-p- methoxybenzyl)-β-lactams that can be readily deprotec

Alpha-(N-Benzenesulfonamido)Cycloalkyl Derivatives

Disclosed are compounds, pharmaceutical compositions containing the compounds, methods for using the compounds and processes for making the compounds. More specifically, the disclosure relates to alpha-(N-benzenesulfonamido)cycloalkyl compounds that may inhibit one or both of: (i) the functioning of a γ-secretase enzyme; or (ii) the production of β-amyloid. Such compounds may be beneficial in the treatment of Alzheimer's disease and other conditions. Representative compounds have the following formula I: wherein: A, R1, and R2 are described herein.

Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form

A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic acid; compound 12, >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction. An optimized version of the chemistry described avoids the use of chromatographic purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound 12 to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is reported. The preparation of the enantiomer of 12 (compound 15) in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is also described.