39155-94-7Relevant articles and documents
Nylon-3 polymers that enable selective culture of endothelial cells
Liu, Runhui,Chen, Xinyu,Gellman, Samuel H.,Masters, Kristyn S.
, p. 16296 - 16299 (2013)
Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomat
SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF
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Page/Page column 94-95, (2022/02/09)
Compounds of formula (I), processes for their production and their use as pharmaceuticals.
Hairpin folding behavior of mixed α/β-peptides in aqueous solution
Lengyel, George A.,Frank, Rebecca C.,Horne, W. Seth
supporting information; experimental part, p. 4246 - 4249 (2011/06/21)
The invention of new strategies for the design of protein-mimetic oligomers that manifest the folding encoded in natural amino acid sequences is a significant challenge. In contrast to the α-helix, mimicry of protein β-sheets is less understood. We report
New compounds
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Page/Page column 9, (2009/07/10)
The present invention encompasses compounds of general formula (1) wherein R1, R2, R4, X, m, n and p are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for preparing a pharmaceutical composition having the above-mentioned properties.
Efficient synthesis of (1R,2S) and (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester derivatives in enantiomerically pure form
Dragovich, Peter S.,Murphy, Douglas E.,Dao, Kimkim,Kim, Sun Hee,Li, Lian-Sheng,Ruebsam, Frank,Sun, Zhongxiang,Tran, Chinh V.,Xiang, Alan X.,Zhou, Yuefen
experimental part, p. 2796 - 2803 (2009/06/28)
A 4-step synthesis of an optically active synthetic intermediate [(1R,2S)-2-(4′-fluorobenzylamino)cyclopentanecarboxylic acid ethyl ester complex with (S)-(+)-mandelic acid; compound 12, >99% de] required for the preparation of a promising HCV NS5B polymerase inhibitor is reported. This process utilizes mandelic acid as a resolving agent, which can be recovered in good yield by a simple extraction. An optimized version of the chemistry described avoids the use of chromatographic purifications making it suitable for large-scale applications. In addition, the straightforward conversion of compound 12 to enantiomerically pure (1R,2S)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is reported. The preparation of the enantiomer of 12 (compound 15) in enantiomerically pure form and the conversion of this entity to (1S,2R)-2-aminocyclopentanecarboxylic acid ethyl ester and the corresponding Boc and Cbz derivatives is also described.
Synthesis and antimalarial evaluation of cyclic β-amino acid-containing dipeptides
Sathe, Manisha,Thavaselvam, Duraipandian,Srivastava, Ashish Kumar,Kaushik, Mahabir Parshad
, p. 432 - 443 (2008/09/17)
This paper describes an efficient synthesis and the antiparasitic evaluation of cyclic β-amino acid-containing dipeptides 3.1-3.6 and 4.1-4.5. The antimalarial properties of all these dipeptides have been evaluated in vitro against Plasmodium falciparum a
NEW COMPOUNDS
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Page/Page column 18, (2008/12/06)
The present invention encompassescompounds of general formula (1) wherein R1 to R4 , X and n are defined as in claim 1, which are suitable for the treatment of ailments characterised byexcessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.
2,4-diamino-pyrimidines as aurora inhibitors
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Page/Page column 18, (2008/06/13)
The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
Design, synthesis and biological evaluation of novel bicyclic β-lactams as potential antimalarials
Nivsarkar, Manisha,Thavaselvam,Prasanna,Sharma, Mamta,Kaushik
, p. 1371 - 1373 (2007/10/03)
A series of bicyclic N-substituted and unsubstituted β-lactams were synthesized and evaluated as targeted potential antimalarials. The compounds MNR4 and MNR5 were found to have highest potency against Plasmodium falciparum in vitro.
Lipase-catalyzed enantioselective ring opening of unactivated alicyclic-fused beta-lactams in an organic solvent.
Forro, Eniko,Fueloep, Ferenc
, p. 1209 - 1212 (2007/10/03)
[reaction: see text] A highly efficient and very simple method was developed for the synthesis of enantiopure beta-amino acids (e.g. cispentacin) and beta-lactams through the enzyme-catalyzed enantioselective ring opening of unactivated alicyclic beta-lac