752207-03-7Relevant academic research and scientific papers
Asymmetric "clip-Cycle" Synthesis of Pyrrolidines and Spiropyrrolidines
Maddocks, Christopher J.,Ermanis, Kristaps,Clarke, Paul A.
supporting information, p. 8116 - 8121 (2020/11/02)
The development of an asymmetric "clip-cycle"synthesis of 2,2- and 3,3-disubstituted pyrrolidines and spiropyrrolidines, which are increasingly important scaffolds in drug discovery programs, is reported. Cbz-protected bis-homoallylic amines were activate
Cobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups
Hori, Hiroto,Arai, Shigeru,Nishida, Atsushi
, p. 4783 - 4788 (2019/05/24)
An efficient synthesis of carbo-and heterocycles using CC, CO and CN bonds under cobalt catalysis is described. The substituents on olefins are key for controlling the regio-and chemoselectivity in the initial hydrogen atom transfer step and quaternary carbons are efficiently constructed under mild conditions. Cyclopropane cleavage and tandem cyclization give highly functionalized bicyclic skeletons in a single operation.
Intramolecular Hydroalkoxylation of Unactivated Alkenes Using Silane-Iodine Catalytic System
Fujita, Shoji,Abe, Masanori,Shibuya, Masatoshi,Yamamoto, Yoshihiko
supporting information, p. 3822 - 3825 (2015/08/18)
A novel catalytic system using I2 and PhSiH3 for the intramolecular hydroalkoxylation of unactivated alkenes is described. NMR study indicated that in situ generated PhSiH2I is a possible active catalytic species. This catalytic system allows an efficient intramolecular hydroalkoxylation of phenyl-, trialkyl-, and 1,1-dialkyl-substituted alkenes as well as a variety of unactivated monoalkyl- and 1,2-dialkyl-substituted alkenes at room temperature. Mechanistic consideration based on significant experimental observations is also discussed.
Platinum-catalyzed intramolecular hydroalkoxylation of γ- and δ-hydroxy olefins to form cyclic ethers
Qian, Hua,Han, Xiaoqing,Widenhoefer, Ross A.
, p. 9536 - 9537 (2007/10/03)
Reaction of 2,2-diphenyl-4-penten-1-ol with a catalytic mixture of [PtCl2(H2C=CH2)]2 (1 mol %) and P(4-C6H4CF3)3 (2 mol %) at 70 °C for 24 h led to the isolation of 2-
