752228-04-9Relevant academic research and scientific papers
DTBB-Catalysed Lithiation of 2,3-Dichloropropene and Related Chloroamines: Synthetic Applications
Huerta, Fernando F.,Gomez, Cecilia,Guijarro, Albert,Yus, Miguel
, p. 3375 - 3388 (1995)
The reaction of 2,3-dichloropropene (1) and different carbonyl compounds (2) with an excess of lithium powder (1:7 molar ratio) in the presence of a catalytic amount of DTBB (5 molpercent) in THF at 0 deg C leads, after hydrolysis with water, to the corre
Bifunctional molecular linchpins: A three-component coupling protocol employing 2-bromoallyltrimethylsilane
Smith III, Amos B.,Duffey, Matthew O.
, p. 1363 - 1366 (2007/10/03)
A new three-component coupling protocol, exploiting 2- bromoallyltrimethylsilane as a bifunctional linchpin, has been developed. The reaction sequence entails the following steps: lithiation of the vinyl bromide, addition of an aromatic or aliphatic aldehyde, execution of a solvent controlled 1,4-Brook rearrangement induced by HMPA to generate an allyl anion, and addition of a reactive second electrophile. Yields are moderate to good.
4,4-di-tert-butylbiphenylcatalysed lithiation of 2,3-dichloropropene: A Barbier-type practical alternative to 2,3-dilithiopropene
Guijarro, Albert,Yus, Miguel
, p. 2011 - 2014 (2007/10/02)
The reaction of 2,3-dichloropropane (1) and different carbonyl compounds (2) with an excess of lithium powder (1:7 molar ratio).
